Controversial tool under scrutiny: could a simple device raise cancer recurrence risk?

NCT ID NCT05687084

Recruiting now Knowledge-focused Sponsor: Universita di Verona Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial is testing whether using a uterine manipulator during minimally invasive hysterectomy for endometrial cancer affects the chance of cancer coming back. About 1,030 women with early-stage endometrial cancer will be randomly assigned to have surgery with or without the device. The goal is to provide clear evidence on whether the manipulator is safe or should be avoided.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Uterine manipulator device
What this could lead to: If it works, this could show that using a uterine manipulator is safe, or that avoiding it reduces cancer recurrence risk.
What could go wrong: This is a large but early-stage trial comparing a device already in use; results may show no difference or be inconclusive.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometrial carcinoma endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL NEOPLASMS

Contacts and locations

Locations

AOUI Verona - University of Verona - Department of Obstetrics and Gynecology
RECRUITING

Verona, 37125, Italy
UOC Ostetricia e Ginecologia, Arcispedale Santa Maria Nuova
RECRUITING

Reggio Emilia, Italy
UOC Ostetricia e Ginecologia, Azienda Ospedaliera Santa Croce e Carle
RECRUITING

Cuneo, Italy, 12100, Italy

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