Controversial tool under scrutiny: could a simple device raise cancer recurrence risk?
NCT ID NCT05687084
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial is testing whether using a uterine manipulator during minimally invasive hysterectomy for endometrial cancer affects the chance of cancer coming back. About 1,030 women with early-stage endometrial cancer will be randomly assigned to have surgery with or without the device. The goal is to provide clear evidence on whether the manipulator is safe or should be avoided.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Uterine manipulator device
What this could lead to
If it works, this could show that using a uterine manipulator is safe, or that avoiding it reduces cancer recurrence risk.
What could go wrong
This is a large but early-stage trial comparing a device already in use; results may show no difference or be inconclusive.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AOUI Verona - University of Verona - Department of Obstetrics and Gynecology
RECRUITINGVerona, 37125, Italy
Contact
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UOC Ostetricia e Ginecologia, Arcispedale Santa Maria Nuova
RECRUITINGReggio Emilia, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UOC Ostetricia e Ginecologia, Azienda Ospedaliera Santa Croce e Carle
RECRUITINGCuneo, Italy, 12100, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••