ENDOMETRIAL CARCINOMA

This early-phase trial tests a personalized vaccine made using quantum computing for 40 people with high-risk or returning endometrial cancer. The vaccine is designed to train the immune system to attack each person's unique tumor. The main goals are to check safety and see if th…

This study planned to test a combination of two drugs, bemarituzumab and bevacizumab, in people with advanced or metastatic endometrial, ovarian, or cervical cancers that have a specific protein (FGFR2b). The goal was to find the safest dose and see if the combination could shrin…

This study tested the drug pembrolizumab in over 1,600 people with various advanced solid tumors that had stopped responding to standard treatments. The goal was to see if the drug could shrink or control the tumors. The trial focused on identifying which patients were most likel…

This study tests whether adding pterostilbene (an antioxidant from blueberries) to the hormone drug megestrol acetate works better than the drug alone in treating endometrial cancer or precancerous changes. About 44 participants take the drug with or without the supplement before…

This trial tests a new antibody drug called acasunlimab (GEN1046) in people with advanced solid tumors that have stopped responding to standard treatments. The study has two parts: first, to find safe doses, and second, to see how well the drug works alone or combined with other …

This early-phase study tests a drug called veliparib combined with two standard chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors who also have liver or kidney dysfunction. The main goals are to find the safest dose and understand how the body p…

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) can better control uterine pre-cancer and stop it from becoming cancer. About 51 women with this pre-cancer condition will receive either the standard drug alone or the …

This study tests a drug called sacituzumab govitecan in 50 people with endometrial cancer that has returned or not responded to chemotherapy. The drug works like a smart bomb, delivering chemotherapy directly to cancer cells. The main goal is to see if it can shrink tumors and he…

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having a baby after treatment. Researchers will use the results to create better information for patients and survivors about balancing cancer care and family planning. T…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study looks at whether long-term inflammation raises the risk of endometrial cancer. Researchers will collect blood, urine, and tissue samples from 191 women having hysterectomy for either benign reasons or endometrial cancer. The goal is to find patterns that could lead to …

This study looks at pelvic floor problems and quality of life in people who survived uterine cancer. Researchers will use questionnaires to gather information from about 310 survivors treated with surgery at MD Anderson between 2006 and 2017. The goal is to learn more about sexua…

This study follows 79 women with gynecologic cancers (cervical, endometrial, vaginal, or vulvar) who had a pelvic exenteration—a surgery removing the lower colon, rectum, and bladder. Researchers track complications, quality of life, and cancer recurrence over time to learn which…

This study was designed to see if an online mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer returning or getting worse. The program would have been compared to standard educational materials. However, the trial was…