Could a diabetes drug help prevent uterine cancer?

NCT ID NCT04576104

Ongoing Disease control Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition will take one or both drugs before their scheduled surgery. Researchers will measure cell growth in tissue samples to see which approach is more effective.

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Conditions

The condition(s) this trial relates to.

atypical endometrial hyperplasia endometrial carcinoma Endometrial Hyperplasia endometrium neoplasm endometrial cancer prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL ATYPICAL HYPERPLASIA/ENDOMETRIOID INTRAEPITHELIAL NEOPLASIA ENDOMETRIAL CARCINOMA

Contacts and locations

Locations

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Northwestern Medicine Central DuPage Hospital

Winfield, Illinois, 60190, United States
Northwestern University

Chicago, Illinois, 60611, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
University of Colorado

Denver, Colorado, 80217-3364, United States
University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455, United States

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