Could a diabetes drug help prevent uterine cancer?
NCT ID NCT04576104
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) works better to control uterine pre-cancer and stop it from turning into cancer. About 51 people with this pre-cancer condition will take one or both drugs before their scheduled surgery. Researchers will measure cell growth in tissue samples to see which approach is more effective.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cedars Sinai Medical Center
Los Angeles, California, 90048, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Northwestern Medicine Central DuPage Hospital
Winfield, Illinois, 60190, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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University of Colorado
Denver, Colorado, 80217-3364, United States
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University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455, United States