Mail-Order HPV test could save lives in underscreened appalachian women

NCT ID NCT04411849

Completed Diagnosis Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether offering at-home HPV self-testing kits can increase cervical cancer screening among women in Appalachia who are overdue for screening. Over 800 women from participating clinics were given either usual care or a self-testing kit along with information and phone support. The goal was to see if the self-testing option makes it easier for women to get screened and catch cervical cancer early.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HPV self-collection kit
What this could lead to: If successful, this approach could make cervical cancer screening more accessible and convenient for women in underserved areas, potentially catching more cases early.
What could go wrong: This is a completed study, so results are available but may not apply to all populations. Self-testing may not be as accurate as a clinic-based test, and some women might still need follow-up care.

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Conditions

The condition(s) this trial relates to.

cervical carcinoma human papilloma virus infection Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CARCINOMA HUMAN PAPILLOMAVIRUS INFECTION

Contacts and locations

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Locations

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
West Virginia University

Morgantown, West Virginia, 26506, United States

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