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E-Cigarettes under the microscope: lung changes revealed

NCT ID NCT03691350

Completed Knowledge-focused Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study looked at how e-cigarettes affect lung cells and cancer-related markers. Researchers used a bronchoscope to collect lung samples from 66 smokers who either continued smoking, switched to e-cigarettes (with or without nicotine), or used nicotine replacement therapy. The goal was to see if e-cigarettes cause changes in the lungs that could be linked to cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Electronic cigarette with or without nicotine
What this could lead to
If successful, this could help identify early lung changes from e-cigarettes and guide future research on cancer risk.
What could go wrong
This is a very early, small study focused on biomarkers, not health outcomes. Results may not apply to all e-cigarette users or predict actual disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CIGARETTE SMOKER CURRENT EVERY DAY SMOKER

Contacts and locations

Locations

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

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