New study tests which Quit-Smoking method works best
NCT ID NCT02271919
First seen Jan 11, 2026 · Last updated Jun 19, 2026 · Updated 27 times
Summary
This study tested whether the drug varenicline helps smokers quit better than nicotine patches and lozenges. Over 600 smokers were randomly assigned to one of the treatments, and all received counseling. The main goal was to see who could stop smoking for at least a week, confirmed by a breath test. This pilot trial aims to find the most effective approach for quitting.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Varenicline and nicotine replacement therapy (patch and lozenge)
What this could lead to
If successful, this could show that varenicline is more effective than nicotine patches and lozenges for quitting smoking, and provide a rescue strategy for those who relapse.
What could go wrong
This is a pilot study, so results are preliminary and may not apply to all smokers. Side effects from varenicline or nicotine replacement are possible, and quitting success rates may still be low.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.