Immune cells injected into skin tumors show promise in early trial
NCT ID NCT07144384
First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times
Summary
This early-phase trial tests whether injecting special immune cells (natural killer cells) directly into skin cancer tumors can safely kill cancer cells. The study compares two types of donor NK cells—standard ones and ones engineered to be more potent—in 40 patients with basal or squamous cell carcinoma. The main goal is to see if the cells enter the tumor and cause any side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Natural killer (NK) cells (standard and TGF-beta-imprinted) injected directly into the tumor
- What this could lead to
- If it works, this could point toward a new way to treat common skin cancers without surgery, using the body's own immune cells.
- What could go wrong
- This is a very early (Phase 1) pilot study with only 40 people. It is designed mainly to check safety and immune activity, not to prove the treatment works. The cells may not shrink tumors or could cause side effects like inflammation or injection reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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