Vitamin a derivative patch could reverse oral precancer
NCT ID NCT07149220
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial tests a sticky patch that releases fenretinide, a vitamin A derivative, directly onto precancerous spots inside the mouth. The goal is to see if the patch can shrink these lesions, reduce their severity under the microscope, and lower genetic changes linked to oral cancer. The study involves healthy volunteers and people with confirmed oral precancer, who apply the patch twice daily for six weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fenretinide mucoadhesive system
What this could lead to
If effective, this patch could offer a non-surgical way to reverse precancerous mouth lesions and lower the risk of oral cancer.
What could go wrong
This is a small early-phase trial, so results may not confirm effectiveness. The patch may cause irritation or fail to shrink lesions.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ohio State University College of Dentistry
Columbus, Ohio, 43210, United States