New light treatment could fight oral cancer without surgery
NCT ID NCT06876038
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial will enroll 65 adults with high-risk oral lesions and follow them for one year to see if the treatment works and if the device is easy to use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
5-Aminolevulinic acid (5-ALA)
What this could lead to
If successful, this could provide an affordable, non-surgical treatment for early oral cancers and pre-cancers, especially in areas with limited resources.
What could go wrong
This is a small, early-phase trial (65 people) testing a new device and drug combination. It may not work for all lesion types, and long-term recurrence or side effects are unknown.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Jawaharlal Nehru Medical College, AMU
Aligarh, Uttar Pradesh, 202002, India
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Karkinos Healthcare Hospitals
Ernākulam, Kerala, India
Contact Phone: •••-•••-•••• Email: •••••@•••••