New light treatment could fight oral cancer without surgery
NCT ID NCT06876038
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial will enroll 65 adults with high-risk oral lesions and follow them for one year to see if the treatment works and if the device is easy to use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 5-Aminolevulinic acid (5-ALA)
- What this could lead to
- If successful, this could provide an affordable, non-surgical treatment for early oral cancers and pre-cancers, especially in areas with limited resources.
- What could go wrong
- This is a small, early-phase trial (65 people) testing a new device and drug combination. It may not work for all lesion types, and long-term recurrence or side effects are unknown.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Jawaharlal Nehru Medical College, AMU
Aligarh, Uttar Pradesh, 202002, India
-
Karkinos Healthcare Hospitals
Ernākulam, Kerala, India
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