ORAL CAVITY CANCER
Clinical trials for ORAL CAVITY CANCER explained in plain language.
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New drug combo aims to shrink Hard-to-Treat head and neck tumors
Disease control Recruiting nowThis study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink tumors in people with advanced head and neck cancer that has returned or spread after initial treatment. About 40 adults whose cancer worsened after first-line therapy will receive the c…
Matched conditions: ORAL CAVITY CANCER
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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New combo aims to shrink head and neck tumors, sparing patients from radical surgery
Disease control Recruiting nowThis study tests giving chemotherapy and an immunotherapy drug before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform a less extensive operation, preserving speech, swallowing, and vision. The trial enrolls 75 adults wit…
Matched conditions: ORAL CAVITY CANCER
Phase: PHASE2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins • Aim: Disease control
Last updated May 11, 2026 20:49 UTC
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New skin flap aims to reduce side effects after head and neck cancer surgery
Knowledge-focused Recruiting nowThis study is testing a new surgical technique to rebuild parts of the mouth or throat after cancer removal. The new method uses a skin flap from the groin area (external pudendal flap) instead of the usual donor sites, hoping to cause fewer complications. The study will include …
Matched conditions: ORAL CAVITY CANCER
Phase: NA • Sponsor: Institut Claudius Regaud • Aim: Knowledge-focused
Last updated May 17, 2026 02:54 UTC
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Lab-Grown tumors may predict immunotherapy success in oral cancer
Knowledge-focused Recruiting nowThis study tests whether a custom lab-grown tumor system can predict how oral cancer responds to immunotherapy before surgery. About 20 adults with stage II-IVB oral cavity cancer will provide a biopsy, receive standard pembrolizumab, and then have surgery. Researchers will analy…
Matched conditions: ORAL CAVITY CANCER
Phase: NA • Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated May 14, 2026 12:03 UTC
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New program aims to cut delays in cancer radiation after surgery
Knowledge-focused Recruiting nowThis study tests a program called ENDURE that helps head and neck cancer patients start radiation therapy within 6 weeks after surgery, as guidelines recommend. About 532 adults will be assigned to either the navigation program or usual care. The goal is to see if the program red…
Matched conditions: ORAL CAVITY CANCER
Phase: NA • Sponsor: Medical University of South Carolina • Aim: Knowledge-focused
Last updated May 07, 2026 18:40 UTC
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Massive cancer registry aims to unlock secrets of the disease
Knowledge-focused Recruiting nowThis study is creating a large database of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand what causes cancer, how it progresses, and how to improve p…
Matched conditions: ORAL CAVITY CANCER
Sponsor: University of Nebraska • Aim: Knowledge-focused
Last updated Apr 29, 2026 15:02 UTC