Could skipping the flap during radiation reduce side effects without harming cancer control?
NCT ID NCT06798922
First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times
Summary
This study tests whether avoiding radiation to the surgical flap (the tissue used to rebuild the mouth after cancer removal) is as effective as standard radiation that treats the whole area. About 348 adults with oral cavity cancer who had reconstructive surgery will be randomly assigned to either flap-sparing or standard radiation. The goal is to see if the gentler approach can maintain cancer control while reducing side effects like mouth and throat problems.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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APHM Marseille
NOT_YET_RECRUITINGMarseille, France
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APHP La Pitié
NOT_YET_RECRUITINGParis, France
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CHIC
NOT_YET_RECRUITINGCréteil, France
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CHU CAEN
NOT_YET_RECRUITINGCaen, France
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Centre Antoine Lacassagne
NOT_YET_RECRUITINGNice, France
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Centre Eugène Marquis
NOT_YET_RECRUITINGRennes, France
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Centre François Baclesse
RECRUITINGCaen, France
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Centre Frédéric Joliot
NOT_YET_RECRUITINGRouen, France
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Centre Georges-François Leclerc
NOT_YET_RECRUITINGDijon, France
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Centre Guillaume le Conquérant
NOT_YET_RECRUITINGLe Havre, France
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Centre Henri Becquerel
NOT_YET_RECRUITINGRouen, France
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Centre Hospitalier
NOT_YET_RECRUITINGCherbourg, France
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Centre Hospitalier
NOT_YET_RECRUITINGLibourne, France
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Centre Jean Perrin
NOT_YET_RECRUITINGClermont-Ferrand, France
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Centre Léon Bérard
NOT_YET_RECRUITINGLyon, France
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Centre Oscar Lambret
NOT_YET_RECRUITINGLille, France
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Centre de la Baie
NOT_YET_RECRUITINGAvranches, France
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Chu Amiens
NOT_YET_RECRUITINGAmiens, France
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Chu Limoges
NOT_YET_RECRUITINGLimoges, France
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Chu Poitiers
NOT_YET_RECRUITINGPoitiers, France
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Chu Reims
NOT_YET_RECRUITINGReims, France
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Chu Rouen
NOT_YET_RECRUITINGRouen, France
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Chu Tours
NOT_YET_RECRUITINGTours, France
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IUCT
NOT_YET_RECRUITINGToulouse, France
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Institut Gustave Roussy
NOT_YET_RECRUITINGVillejuif, France
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Institut Jean Godinot
NOT_YET_RECRUITINGReims, France
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Institut Régional du Cancer Val D'aurelle
NOT_YET_RECRUITINGMontpellier, France
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Institut de Cancérologie de Lorraine
NOT_YET_RECRUITINGNancy, France
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Institut de Cancérologie de l'Ouest
NOT_YET_RECRUITINGAngers, France
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Institut de Cancérologie de l'Ouest
NOT_YET_RECRUITINGSaint-Herblain, France
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