Could skipping the flap during radiation reduce side effects without harming cancer control?
NCT ID NCT06798922
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether avoiding radiation to the surgical flap (the tissue used to rebuild the mouth after cancer removal) is as effective as standard radiation that treats the whole area. About 348 adults with oral cavity cancer who had reconstructive surgery will be randomly assigned to either flap-sparing or standard radiation. The goal is to see if the gentler approach can maintain cancer control while reducing side effects like mouth and throat problems.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHM Marseille
NOT_YET_RECRUITINGMarseille, France
Contact
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APHP La Pitié
NOT_YET_RECRUITINGParis, France
Contact Email: •••••@•••••
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CHIC
NOT_YET_RECRUITINGCréteil, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU CAEN
NOT_YET_RECRUITINGCaen, France
Contact Email: •••••@•••••
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Centre Antoine Lacassagne
NOT_YET_RECRUITINGNice, France
Contact
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Centre Eugène Marquis
NOT_YET_RECRUITINGRennes, France
Contact Email: •••••@•••••
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Centre François Baclesse
RECRUITINGCaen, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Georges-François Leclerc
NOT_YET_RECRUITINGDijon, France
Contact
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Centre Guillaume le Conquérant
NOT_YET_RECRUITINGLe Havre, France
Contact
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Centre Henri Becquerel
NOT_YET_RECRUITINGRouen, France
Contact Email: •••••@•••••
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Centre Hospitalier
NOT_YET_RECRUITINGLibourne, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Jean Perrin
NOT_YET_RECRUITINGClermont-Ferrand, France
Contact Email: •••••@•••••
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Centre Léon Bérard
NOT_YET_RECRUITINGLyon, France
Contact Email: •••••@•••••
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Centre Oscar Lambret
NOT_YET_RECRUITINGLille, France
Contact Email: •••••@•••••
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Chu Amiens
NOT_YET_RECRUITINGAmiens, France
Contact Email: •••••@•••••
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Chu Poitiers
NOT_YET_RECRUITINGPoitiers, France
Contact Email: •••••@•••••
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Chu Rouen
NOT_YET_RECRUITINGRouen, France
Contact Email: •••••@•••••
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Chu Tours
NOT_YET_RECRUITINGTours, France
Contact
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IUCT
NOT_YET_RECRUITINGToulouse, France
Contact Email: •••••@•••••
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Institut Gustave Roussy
NOT_YET_RECRUITINGVillejuif, France
Contact Email: •••••@•••••
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Institut Jean Godinot
NOT_YET_RECRUITINGReims, France
Contact Email: •••••@•••••
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Institut Régional du Cancer Val D'aurelle
NOT_YET_RECRUITINGMontpellier, France
Contact
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Institut de Cancérologie de Lorraine
NOT_YET_RECRUITINGNancy, France
Contact Email: •••••@•••••
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Institut de Cancérologie de l'Ouest
NOT_YET_RECRUITINGAngers, France
Contact Email: •••••@•••••
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Institut de Cancérologie de l'Ouest
NOT_YET_RECRUITINGSaint-Herblain, France
Contact Email: •••••@•••••