Can heat boost chemo? early trial tests thermotherapy for head and neck cancer
NCT ID NCT07690618
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This early-phase trial tests whether adding mild heat therapy (thermotherapy) to standard chemoradiation is safe and tolerable for people with advanced head and neck cancer. The heat, applied once a week, aims to make the cancer more sensitive to treatment. The study includes two groups: one receiving chemoradiation plus heat, and another receiving radiation alone plus heat. The main goal is to find the best heat dose and check for side effects like mouth stiffness or burns.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- thermotherapy (mild hyperthermia)
- What this could lead to
- If successful, this could lead to a new, safe way to boost the effectiveness of standard chemoradiation for head and neck cancer, potentially reducing tumor recurrence.
- What could go wrong
- This is a very early phase I trial with only 30 participants, so it is primarily testing safety and dosing, not yet effectiveness. Adding heat may increase side effects like mouth stiffness, burns, or tissue damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HEAD AND NECK CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Erasmus Medical Center
Rotterdam, South Holland, 3015 CD, Netherlands
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can laser or ozone therapy better soothe cancer-related mouth pain? a head-to-head comparison
- Open-Face mask may improve comfort and accuracy in head and neck cancer radiation
- Can a new nucleotide analogue boost cancer treatment?
- Can a short course of immunotherapy and radiation shrink head and neck tumors before surgery?
- Can standard cancer treatment wake up the immune system? a study investigates.
- Can a Two-Drug attack shrink Hard-to-Treat head and neck tumors?