Erasmus Medical Center

This trial investigates whether adding up to three corticosteroid injections to standard exercise therapy improves pain and function in adults with chronic midportion Achilles tendinopathy. Participants receive either the steroid injection or a placebo (lidocaine only), alongside…

This study tests whether giving chemotherapy after surgery can prevent rectal cancer from returning in people who have a positive ctDNA blood test (a sign of leftover cancer cells). About 103 adults with high-risk rectal cancer will either receive chemo or be observed. The goal i…

This study tests whether a structured, tailored nutritional care program helps children who need nutritional support after leaving the hospital. About 260 children from newborns to 18 years old will take part. Parents fill out questionnaires on eating behavior, stress, and food d…

This study tests a new treatment for stomach cancer that has spread to the lining of the belly (peritoneal metastases). About 55 patients will receive chemotherapy directly into the abdomen along with standard intravenous chemotherapy, and possibly immunotherapy or targeted thera…

This study tests whether a home-based computer cognitive training program (RehaCom) can improve attention and memory in adults with acquired brain injury, including stroke. Thirty participants will either receive the home program plus weekly in-person sessions, or standard in-per…

This study tests a new way to deliver radiation to kidney tumors using advanced imaging to better target the cancer while avoiding healthy tissue. About 40 adults with non-spread kidney cancer will receive this tailored radiotherapy. The goal is to reduce damage to the kidney and…

This study compares two common drugs, cyclosporine and methotrexate, to treat moderate-to-severe alopecia areata in children aged 2-17. The goal is to see which medicine helps regrow hair better over 9 months. Participants and their parents choose which treatment to try, and doct…

This study tests whether giving two different chemotherapy regimens one after the other before surgery can help people with esophageal cancer that has spread to nearby lymph nodes. About 216 adults with resectable cancer will receive either FLOT followed by CROSS or CROSS followe…

This study tests whether adding an intra-aortic balloon pump (IABP) to standard ECMO support helps more people with severe cardiogenic shock recover enough to come off the heart-lung machine. About 430 adults will be randomly assigned to get ECMO alone or ECMO plus IABP. The main…

This study tests a new device called the VariPulse catheter, which uses short electrical pulses to treat atrial fibrillation (AF), a common heart rhythm problem. Twenty adults with AF will get this treatment, and after 2-3 months, doctors will check if the treated veins are still…

This study tests a tool called SCALE-EYE that helps doctors measure the size of polyps during a colonoscopy. The goal is to see if it works better than current methods and can reduce the number of follow-up colonoscopies, waste, and carbon footprint. About 241 people aged 55-80 h…

This study tests whether a program called HoorToren can help 10-11 year olds use headphones and earbuds more safely. About 600 children and their parents will take part, with half receiving the lessons and home assignments. Researchers will measure listening habits through survey…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study tests whether giving iron infusions after a minimally invasive heart valve replacement (TAVI) helps patients with aortic stenosis and iron deficiency feel better and walk farther. About 402 older adults will be randomly assigned to receive iron or standard care. Resear…

This study tests whether a 12-week home-based high intensity interval training program can improve exercise capacity in people aged 12 to 45 with a congenital heart defect that required a surgical connection between the right ventricle and pulmonary artery. Participants are rando…

This study tests whether listening to music before and after electroconvulsive therapy (ECT) can reduce postictal agitation—a common side effect where patients become restless or confused after treatment. Researchers will enroll 92 adults with severe depression undergoing ECT. Ha…

This study is testing whether people with pulmonary fibrosis can safely replace half of their regular clinic visits with home monitoring. Participants will use a home spirometer, pulse oximeter, and a smartphone app to track their health and communicate with their care team. The …

This study checks if it's possible to send some hospital patients home early and monitor them remotely using a smartphone app and vital sign tracking. Researchers want to see if at least 30% of eligible patients can safely use this virtual ward. The goal is to reduce hospital sta…

This study looks at whether a quick bedside test can measure fibrinogen levels in trauma patients with severe bleeding within minutes, instead of the usual 30-45 minutes. Fibrinogen helps blood clot, and low levels can worsen bleeding. The test is being checked for feasibility an…

This study follows 150 children and adults worldwide who have a rare genetic condition affecting CAMK2 genes. Researchers will track development, seizures, behavior, and social skills over time. The goal is to create a clear picture of how the disorder progresses, which can help …

This study is creating a standard set of questions and measurements to evaluate dental implants from both the dentist's and patient's point of view. Researchers will follow 1000 patients in the Netherlands and Spain who are getting dental implants. The goal is to combine clinical…

This study looks at whether a small drop of blood from a finger-prick device can reliably detect tumor DNA in 35 adults with colorectal cancer that has spread to the liver. Researchers will compare results from the finger-prick sample to a standard arm-vein blood draw to see if t…

This study investigates the 'measles paradox'—how measles can temporarily weaken the immune system while also providing lifelong protection. Researchers will track immune memory cells in 300 adults before and after measles infection. The goal is to understand how measles causes i…

This study looks at whether bright light therapy can help reduce depressive symptoms in adults with intellectual disabilities. Researchers will see how acceptable and practical this treatment is in two care organizations. About 105 participants, including staff and patients, will…

This study tracks respiratory viruses in 250 healthcare and animal workers in the Netherlands, whether they have symptoms or not. Researchers will test for viruses directly and monitor immune changes over time. The goal is to catch new or emerging viruses early and learn how the …