Balloon pump may boost ECMO success in shock patients

NCT ID NCT05913622

Recruiting now Disease control Sponsor: Erasmus Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding an intra-aortic balloon pump (IABP) to standard ECMO support helps more people with severe cardiogenic shock recover enough to come off the heart-lung machine. About 430 adults will be randomly assigned to get ECMO alone or ECMO plus IABP. The main goal is to see who can be weaned from ECMO within 30 days without needing a heart transplant or permanent heart pump.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intra-aortic balloon pump (IABP)
What this could lead to: If it works, this could show that adding an IABP helps more patients successfully come off ECMO without needing a heart transplant or long-term heart pump.
What could go wrong: This is an early-stage platform trial, so results may not be definitive. The IABP itself carries risks like bleeding or vessel damage, and the benefit over ECMO alone is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiogenic shock Shock, Cardiogenic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOGENIC SHOCK

Contacts and locations

Locations

AZ Sint-Jan Brugge
RECRUITING

Bruges, Belgium
Amphia hospital
NOT_YET_RECRUITING

Breda, North Brabant, 4818 CK, Netherlands
Amsterdam University Medical Center
NOT_YET_RECRUITING

Amsterdam, North Holland, 1105 AZ, Netherlands
Antonius hospital
NOT_YET_RECRUITING

Nieuwegein, Utrecht, 3435 CM, Netherlands
Catharina hospital
NOT_YET_RECRUITING

Eindhoven, North Brabant, 5623 EJ, Netherlands
Erasmus Medical Center
RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Haga ziekenhuis
NOT_YET_RECRUITING

The Hague, South Holland, 2545 AA, Netherlands
Leiden University Medical Center
NOT_YET_RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands
Maastricht UMC
RECRUITING

Maastricht, Netherlands
OLVG
RECRUITING

Amsterdam, Netherlands
Radboud UMC
RECRUITING

Nijmegen, Netherlands
UZ Gent
RECRUITING

Ghent, Belgium
University Medical Center Utrecht
NOT_YET_RECRUITING

Utrecht, Utrecht, 3584 CX, Netherlands
ZOL Genk
RECRUITING

Genk, Belgium

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