Cardiogenic shock

This trial tests an external ventricular assist device that temporarily takes over the heart's pumping function in people with cardiogenic shock—a condition where the heart can't pump enough blood. The study enrolls 40 adults who have shock after heart surgery, can't come off a h…

This study tests a compact heart-lung machine called Cardiohelp in 50 children with severe heart failure. The device supports the heart for up to 30 days while kids recover or await a transplant. The trial also compares two blood thinners to see which causes fewer bleeding or clo…

This trial tests whether ivabradine, a drug that lowers heart rate, can help people recover from cardiogenic shock—a life-threatening condition where the heart can't pump enough blood—after a heart attack. Participants receive either ivabradine or a placebo for three days, and do…

This early study is testing a new heart pump device (Magenta Elevate) in 10 people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. The device is inserted through a blood vessel to help the heart pump. Researchers are checking if it is…

This early-stage trial tests a new antibody drug called procizumab in 130 people with cardiogenic shock, a life-threatening condition where the heart cannot pump enough blood. The drug blocks a protein called DPP3, which is linked to worse outcomes. The main goal is to check safe…

This study tests whether a personalized blood transfusion approach, based on oxygen levels, is better than the standard method for people on a heart-lung machine (ECMO) due to severe heart failure. About 236 adults will be randomly assigned to one of two strategies to see which r…

This study tests whether a digital platform that monitors blood pressure and symptoms at home can improve outcomes for people with early cardiogenic shock, a serious heart condition. About 472 patients will be split into two groups: one gets standard discharge care, the other get…

This study tests a minimally invasive procedure to repair a leaky heart valve in people with cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 144 adults in intensive care will be randomly assigned to either standard medical therapy or…

This study tests whether drugs that increase the heart's pumping ability (inotropes) benefit patients in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 346 critically ill adults will receive either dobutamine, milrinone, or a placeb…

This study tests whether adding a balloon pump (IABP) to standard ECMO support helps the heart recover better in people with severe cardiogenic shock. About 104 adults will be randomly assigned to get ECMO alone or ECMO plus the balloon pump. Researchers will measure heart functi…

This study tests whether replacing a narrowed heart valve right away (within 12 hours) helps people with severe aortic stenosis who are in cardiogenic shock, compared to the usual approach of stabilizing them in the ICU first. Thirty participants will be randomly assigned to one …

This study tests whether adding a balloon pump early to reduce pressure on the heart improves survival and recovery in 298 adults on ECMO for severe cardiogenic shock. Participants are randomly assigned to early preventive unloading or standard care with rescue unloading only if …

Cardiogenic shock is a life-threatening condition where the heart can't pump enough blood. This study tests whether setting a personalized blood pressure target based on central venous pressure improves survival and reduces organ damage compared to the standard fixed target. Abou…

This study tests whether using less of the drug noradrenaline, by aiming for a lower blood pressure target (55 mmHg instead of 65 mmHg), can improve survival and reduce severe kidney failure in people with cardiogenic shock after a heart attack. About 776 adults will be randomly …

This study looks at whether placing a special balloon pump (IABP) early after starting ECMO can improve survival in adults with cardiogenic shock—a life-threatening condition where the heart can't pump enough blood. About 358 participants will be randomly assigned to get the ball…

This pilot study tests whether an implanted heart pressure monitor (CardioMEMS) can help prevent complications in 40 patients who survived cardiogenic shock. Participants will have the device implanted and receive regular pressure checks and medication adjustments. The goal is to…

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study is for adults with severe cardiogenic shock who need a heart-lung machine (ECMO) and have developed acute kidney injury. Researchers want to see if starting dialysis (continuous renal replacement therapy) earlier improves survival and reduces long-term kidney dependenc…

This study tests whether using a heart-lung machine (ECMO) before a high-risk aortic valve replacement can prevent death, cardiac arrest, or emergency surgery. It includes 30 adults with severe aortic stenosis who are unstable or have complex anatomy. Participants receive ECMO su…

This study tests if adding the drug landiolol to the fluid that protects the heart during mitral valve surgery can reduce a serious complication called low cardiac output syndrome, where the heart struggles to pump enough blood after surgery. About 1500 adults having elective mit…

This study tests whether adding an intra-aortic balloon pump (IABP) to standard ECMO support helps more people with severe cardiogenic shock recover enough to come off the heart-lung machine. About 430 adults will be randomly assigned to get ECMO alone or ECMO plus IABP. The main…

This study tests whether using a special heart monitor (pulmonary artery catheter) early in the hospital can lower the risk of death for people in cardiogenic shock caused by heart failure. About 400 adults with severe heart failure and shock will be randomly assigned to get eith…

This study tests a temporary heart pump called iVAC 2L in 100 patients undergoing high-risk angioplasty. The pump helps stabilize blood flow during the procedure. Researchers will track deaths, heart attacks, strokes, and other complications for up to a year to see if the device …

This study looks at whether giving a special ketone drink through a feeding tube is safe and practical for people with severe heart failure. The goal is to see if it can help the heart use energy better. The study involves 12 participants with very weak hearts who are in the hosp…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study looks at whether measuring the heart's 'reserve'—its ability to pump harder under stress—can predict how patients with advanced heart failure will do. Five patients with weak hearts (ejection fraction 40% or less) will be randomly assigned to receive the drug milrinone…

This observational study will follow 600 adults hospitalized with acute heart failure or cardiogenic shock. Researchers will collect information from routine care, plus extra blood and urine samples, to see if they can better identify different types of shock and predict who is a…

This study observes up to 350 patients who had a heart attack complicated by cardiogenic shock and received an Impella CP heart pump during artery-opening procedures. Researchers will track safety issues like major bleeding, limb problems, and kidney injury, as well as survival a…

This study, called CEPEC, is a large platform trial enrolling 5,500 ICU patients across multiple countries. It tests different approaches to three common ICU treatments: how low to let blood pressure go with vasopressors, when to give platelet transfusions, and how to provide nut…

This study gathers detailed, real-time information from the Impella heart pump and standard hospital monitors in 125 people with cardiogenic shock. The goal is to better understand how the pump and the body's vital signs work together. No new treatment is being tested; instead, r…

This registry will collect health information from 8,000 patients with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will track what treatments patients receive and how they fare, including survival rates in the hosp…

This observational study follows 800 adults admitted to a cardiology department with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will review medical records from 2017 onward to see how treatments and survival rates…

This observational study looks at how the right side of the heart adapts when critically ill patients receive fluids. Researchers will use ultrasound to measure heart function before and after fluid administration in 100 adults. The goal is to understand why some patients develop…

This study looks at data from 100 adults with cardiogenic shock who received an Impella 5.5 heart pump. Researchers aim to build a tool that uses pump signals to predict whether a patient's own heart will recover. The goal is to improve decision-making and reduce complications li…

This study tests whether paramedics can safely place a small tube in the leg artery of people having a cardiac arrest outside the hospital. The tube allows continuous blood pressure monitoring, which may help doctors give the right amount of medication to keep the heart pumping. …

This study is a registry that will follow 3000 people hospitalized with cardiogenic shock, a life-threatening condition where the heart suddenly cannot pump enough blood. Researchers will collect information on how patients are treated and what happens to them over time. The goal…

This study looks at 100 ICU patients with shock who are on a breathing machine. Doctors will use an ultrasound to measure the size of a vein and artery in the leg. They want to see if this ratio can tell whether giving fluids will help the heart pump more blood. The goal is to fi…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study looks at 26 people with severe heart failure who are in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. Researchers will measure specific markers in the blood related to inflammation and blood vessel health. The goal is to bette…

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study looks at whether having a dedicated cardiogenic shock team helps more people survive severe heart failure or heart attack. Researchers will compare survival rates before and after the team was created, using data from up to 3,000 patients. The goal is to see if this te…

This observational pilot study at Thomas Jefferson University will enroll 20 adults with cardiogenic shock who are already receiving an intra-aortic balloon pump (IABC). Researchers will measure baseline arterial compliance (how stiff the arteries are) and then track heart functi…

This study looks at a severe condition called mixed cardiogenic-vasoplegic shock, where the heart fails to pump and blood vessels widen too much. Researchers will review medical records from 2,500 patients in three French hospitals to understand who gets this condition and how th…

This registry follows 350 people who survived cardiogenic shock (a severe form of heart failure) after they leave the hospital. Researchers want to learn about deaths, hospital readmissions, and other challenges patients face in the months and years after discharge. The goal is t…

This study looks at how genes affect the immune system and treatment responses in people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect blood samples from 300 patients to identify genetic patterns li…

This study observes 128 critically ill ICU patients to see how two common sedatives—propofol and ketamine—affect the risk of severe drops in blood pressure or cardiac arrest during emergency intubation. Propofol can lower blood pressure, while ketamine may help maintain stability…

This registry is tracking 3,000 critically ill patients who receive the CytoSorb blood-filtering device in real-world intensive care settings. The goal is to collect data on how the device is used and whether it relates to patient survival. It covers many conditions like sepsis, …