Do Heart-Strengthening drugs actually help in shock? major trial aims to find out
NCT ID NCT05267886
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether drugs that increase the heart's pumping ability (inotropes) benefit patients in cardiogenic shock, a life-threatening condition where the heart can't pump enough blood. About 346 critically ill adults will receive either dobutamine, milrinone, or a placebo (saline). The main goal is to see if these drugs reduce death or serious complications within the first 12 hours. After that, doctors can choose any treatment. The trial is double-blind, so neither patients nor doctors know who gets the real drug.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dobutamine or Milrinone (heart-pumping drugs)
What this could lead to
If it works, this could show that inotropes improve survival and reduce complications in cardiogenic shock, guiding standard care.
What could go wrong
This is a Phase 4 trial, but the drugs are already used in practice. The placebo group may worsen, and results may not apply to all shock types.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hamilton Health Sciences
RECRUITINGHamilton, Ontario, L8L 2X2, Canada
Contact
Contact Phone: •••-•••-••••
Contact
Contact
Contact
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Mayo Clinic
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
Contact Email: •••••@•••••
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Contact
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University of Ottawa Heart Institute
RECRUITINGOttawa, Ontario, K1Y4W7, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact