Massive ICU trial aims to settle debates on blood pressure, platelets, and nutrition

NCT ID NCT06605144

Recruiting now Knowledge-focused Sponsor: Université de Sherbrooke Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This study, called CEPEC, is a large platform trial enrolling 5,500 ICU patients across multiple countries. It tests different approaches to three common ICU treatments: how low to let blood pressure go with vasopressors, when to give platelet transfusions, and how to provide nutrition. The goal is to find out which strategies lead to better survival and recovery. By comparing treatments already used in practice, the results could directly guide doctors' decisions in the ICU.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vasopressors, platelet transfusions, and nutrition interventions
What this could lead to: If successful, this trial could help doctors make better decisions about routine ICU care, potentially improving survival and recovery for critically ill patients.
What could go wrong: This is a large, pragmatic trial, but results may not apply to all ICU patients. The interventions are already in use, so no major new risks are expected, but the study may not find clear winners among the options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiogenic shock hypotensive disorder nutritional disorder thrombocytopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTENSIVE CARE UNIT (ICU) NUTRITION PLATELET VASOPRESSOR

Contacts and locations

Locations

Auckland City Hospital
NOT_YET_RECRUITING

Auckland, New Zealand
CIUSSS de l'Estrie - CHUS
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Centre hospitalier de l'Université de Montréal (CHUM)
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Hamilton Health Sciences - Juravinski Hospital
RECRUITING

Hamilton, Ontario, L8V 1C3, Canada
Intensive Care National Audit and Research Centre (coordinating centre for sites in UK. Sites to be determined)
NOT_YET_RECRUITING

London, United Kingdom
Niagara Health
RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada
Scarborough Health Network
RECRUITING

Scarborough Village, Ontario, M1P 2V5, Canada
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada

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