Can a simple pill stabilize blood pressure after spinal cord injury?

NCT ID NCT05839652

Recruiting now Disease control Sponsor: James J. Peters Veterans Affairs Medical Center Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial compares two blood pressure medications—midodrine and droxidopa—against compression stockings and a placebo to see which best stabilizes blood pressure in people with spinal cord injury. Participants have a traumatic injury between C1 and T6, are at least a year post-injury, and are non-ambulatory. The study measures blood pressure, brain blood flow, and symptoms like dizziness and fatigue during tilt-table tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Midodrine hydrochloride and droxidopa (blood pressure medications), plus compression stockings
What this could lead to: If successful, this could identify the most effective drug and dose to manage orthostatic hypotension in people with spinal cord injury, improving daily comfort and safety.
What could go wrong: This is a small Phase 4 trial with 25 participants, so results may not apply to everyone. Medications may cause side effects like high blood pressure when lying down.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder orthostatic hypotension spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOTENSION

Contacts and locations

Locations

James J Peters VA Medical Center
RECRUITING

The Bronx, New York, 10468, United States
Kessler Foundation
RECRUITING

West Orange, New Jersey, 07052, United States

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