Heart drug during surgery may cut deadly complication risk

NCT ID NCT06793670

Recruiting now Disease control Sponsor: Università Vita-Salute San Raffaele Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if adding the drug landiolol to the fluid that protects the heart during mitral valve surgery can reduce a serious complication called low cardiac output syndrome, where the heart struggles to pump enough blood after surgery. About 1500 adults having elective mitral valve repair or replacement will be randomly assigned to receive landiolol or a placebo. The goal is to see if landiolol lowers the need for strong heart medications, mechanical support, or kidney dialysis after surgery.

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Conditions

The condition(s) this trial relates to.

Cardiac Output, Low cardiogenic shock heart failure mitral valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC FAILURE LOW CARDIAC OUTPUT SYNDROME

Contacts and locations

Locations

A. O. Ordine Mauriziano di Torino
RECRUITING

Torino, TO, Italy
AOR San Carlo
RECRUITING

Potenza, Italy
AOU Careggi
RECRUITING

Florence, Italy
AOU Policlinico Paolo Giaccone
RECRUITING

Palermo, Italy
AOU di Alessandria
RECRUITING

Alessandria, Italy
ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, Italy
Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia
RECRUITING

Foggia, Italy
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, Italy
Azienda Ospedaliero Universitaria Policlinico "G.Rodolico - San Marco"
RECRUITING

Catania, 95123, Italy
IRCCS San Martino di Genova
RECRUITING

Genova, Italy
Maria Cecilia Hospital S.p.A.
RECRUITING

Ravenna, Italy
Ospedale Cesare Arrigo
RECRUITING

Alessandria, Piedmont, 15121, Italy
Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy

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