Which ventilator mode is best for heart patients? a pilot study aims to find out

NCT ID NCT07656259

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-controlled (delivers air at a set pressure). The study includes adults in the cardiac ICU expected to need a ventilator for more than 12 hours. The main goal is to see how well doctors can stick to the assigned mode and how quickly it starts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mechanical ventilation modes (volume-controlled vs. pressure-controlled)
What this could lead to: If feasible, this could pave the way for a larger trial to determine which ventilation mode is safer for patients with heart problems.
What could go wrong: This is a small pilot study focused on feasibility, not on proving which mode is better. Results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

cardiac arrest cardiogenic shock cardiovascular disorder Critical Illness pulmonary edema pulmonary hypertension respiratory failure Shock, Cardiogenic systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIO VASCULAR DISEASE CARDIOGENIC PULMONARY OEDEMA CARDIOGENIC SHOCK CARDIOPULMONARY CRITICAL ILLNESS MECHANICAL VENTILATION RESPIRATION FAILURE

Contacts and locations

Locations

Mayo Clinic, 1216 Second Street SW
RECRUITING

Rochester, Minnesota, 55905, United States

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