Could a simple filter tame the deadly inflammation of heart shock?

This study tests whether adding an Oxiris membrane—a special blood filter that removes toxins and inflammatory molecules—to the ECMO circuit can reduce the harmful inflammation and organ damage that often occurs when blood flow is restored after cardiogenic shock. The trial enrolls adults with refractory cardiogenic shock who are already on ECMO and need continuous kidney replacement therapy. Participants are randomly assigned to receive either the Oxiris membrane or a standard filter for 24 hours, with blood tests measuring inflammatory markers over several days.