New chemo combo aims to boost survival in tough esophageal cancer

NCT ID NCT06161818

Recruiting now Disease control Sponsor: Erasmus Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving two different chemotherapy regimens one after the other before surgery can help people with esophageal cancer that has spread to nearby lymph nodes. About 216 adults with resectable cancer will receive either FLOT followed by CROSS or CROSS followed by FLOT. The goal is to see if this intensive approach improves how long patients live without the cancer coming back.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus esophageal adenocarcinoma esophageal cancer Esophageal Neoplasms gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOCARCINOMA OF THE ESOPHAGUS ESOPHAGEAL CANCER

Contacts and locations

Locations

Amsterdam UMC
NOT_YET_RECRUITING

Amsterdam, North Holland, Netherlands
Antoni van Leeuwenhoek/Nederlands Kanker Instituut
NOT_YET_RECRUITING

Amsterdam, Netherlands
Catharina Ziekenhuis
NOT_YET_RECRUITING

Eindhoven, North Brabant, Netherlands
Elisabeth Tweesteden Ziekenhuis
NOT_YET_RECRUITING

Tilburg, North Brabant, Netherlands
Erasmus Medical Centre
RECRUITING

Rotterdam, South Holland, Netherlands
Frisius medisch centrum
NOT_YET_RECRUITING

Leeuwarden, North Brabant, Netherlands
Gelre ziekenhuis
NOT_YET_RECRUITING

Apeldoorn, Netherlands
Leids Universitair Medisch Centrum
NOT_YET_RECRUITING

Leiden, Netherlands
Radboud Universitair Medisch Centrum
NOT_YET_RECRUITING

Nijmegen, Netherlands
Ziekenhuisgroep Twente
NOT_YET_RECRUITING

Almelo, Netherlands

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