Iron shots after valve surgery: could they boost energy and walking ability?

NCT ID NCT07370688

Recruiting now Symptom relief Sponsor: Erasmus Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving iron infusions after a minimally invasive heart valve replacement (TAVI) helps patients with aortic stenosis and iron deficiency feel better and walk farther. About 402 older adults will be randomly assigned to receive iron or standard care. Researchers will measure quality of life and exercise capacity 24 weeks after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ferric carboxymaltose (iron infusion)
What this could lead to: If it works, this could show that correcting iron deficiency after TAVI helps patients feel better and walk farther.
What could go wrong: This is a Phase 4 trial, but the benefit of iron in this setting is not proven. Some patients may not improve, and iron infusions carry rare risks like allergic reactions.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis cardiovascular disorder Iron Deficiencies iron deficiency anemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE STENOSIS CARDIOVASCULAR DISEASES IRON-DEFICIENCY TAVI(TRANSCATHETER AORTIC VALVE IMPLANTATION)

Contacts and locations

Locations

Erasmus University Medical Center
RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands

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