AORTIC VALVE STENOSIS

This study aims to find the safest way to use a drug called protamine after a minimally invasive heart valve replacement (TAVI). Protamine helps reduce bleeding but can cause severe allergic reactions. Researchers will compare giving protamine to every patient versus only giving …

This study aims to compare how two different types of replacement heart valves perform, especially during physical activity. Researchers will enroll 90 patients with severe aortic stenosis who are getting a valve replacement procedure called TAVR. Using special heart scans during…

This study is testing a new heart valve replacement system called GEMINUS for people with severe aortic stenosis, a condition where the heart's aortic valve narrows and restricts blood flow. Researchers will implant the device in 30 patients through a minimally invasive procedure…

This study aims to see how well a newer model of artificial heart valve performs over many years. Researchers will follow 150 patients with severe aortic valve narrowing who receive this specific valve. They will use heart ultrasounds to check the valve's function at regular inte…

This study aims to understand the best way to treat patients when a previously implanted keyhole heart valve fails. It will follow 550 patients who receive a second keyhole valve inside the old one, have open-heart surgery, or receive medication only. The goal is to document shor…

This study aims to determine whether early valve replacement or careful monitoring works better for older adults with moderate aortic valve narrowing. Researchers will compare two approaches: implanting a new heart valve through a minimally invasive procedure versus regular check…

This trial is testing if adding a once-daily pill called enavogliflozin to standard care can help prevent major heart problems in people who have had a minimally invasive heart valve replacement and also have a specific type of heart failure. The study will enroll about 1,040 par…

This study is testing a technique called intravascular lithotripsy (IVL), which uses tiny shockwaves, to break up severe calcium deposits in the leg arteries of patients who need a heart valve replacement. The goal is to see if clearing this blockage safely allows doctors to perf…

This study is testing if patients who have a minimally invasive heart valve replacement (TAVI) can go home the same day safely if they use special remote monitoring devices. Researchers want to see if this approach reduces total time spent in the hospital and prevents readmission…

This study compares two different types of replacement heart valves for patients whose previous biological valve has worn out. Researchers will randomly assign 104 patients to receive either the self-expanding Allegra valve or the balloon-expandable Edwards valve, both implanted …

This registry aims to track the safety and performance of a specific type of new heart valve (Myval) used in a minimally invasive procedure for patients with severe, symptomatic aortic stenosis. It will follow 150 patients in Portugal who receive this valve implant to monitor for…

This study is tracking the safety and performance of the VitaFlow Liberty device, which replaces a narrowed aortic heart valve without open-heart surgery. It will follow 122 patients with severe aortic stenosis who are at high risk for traditional surgery. The main goal is to see…

This study is testing if a second, quick balloon inflation during a minimally invasive heart valve replacement (TAVI) makes the new valve work better and last longer. Patients with severe aortic valve narrowing will be randomly assigned to receive either the standard procedure or…

This study is testing a new, less invasive heart valve called the SAPIEN X4. It is for people whose previous surgical valve replacement is now failing and who are at high risk for another open-heart surgery. Doctors will place the new valve inside the old one using a catheter thr…

This study aims to find the best way to manage pain after a minimally invasive heart valve replacement (TAVI). Researchers will compare two different types of ultrasound-guided nerve blocks and standard local numbing in 60 patients. The goal is to see which method best reduces pa…

This study is testing whether giving iron infusions to older patients with iron deficiency after a minimally invasive heart valve replacement (TAVI) helps them feel better and walk farther. Researchers will compare patients who receive iron infusions to those who receive standard…

This study is testing a new type of heart scan to see if it can detect specific chemical changes in the hearts of people with aortic stenosis or diabetes. Researchers will compare scans from 96 participants—including healthy volunteers and people with these conditions—to understa…

This small pilot study is testing whether a new device called HemoCept can accurately measure blood volume and heart efficiency during aortic valve replacement surgery. Researchers will compare the device's readings with standard heart ultrasound measurements taken before and aft…

This study aims to develop and test new software that makes heart MRI scans easier to analyze. Researchers want to create automated tools that can measure blood flow and pressure inside the heart without invasive procedures. The study involves patients with severe aortic valve na…

This study aims to collect heart scan data to train a computer program to predict how well a new heart valve will work after a minimally invasive replacement procedure. Researchers will enroll 40 patients with severe aortic stenosis who are getting a TAVI valve, asking them to ha…

This study aims to understand how moderate heart valve disease gets worse over time. It will follow 10,000 adults in China, using regular heart scans and blood tests to track their condition. The goal is to find early warning signs and see how different treatments affect the dise…