AORTIC VALVE STENOSIS

This study compares two approaches for people with moderate aortic stenosis, a heart valve condition that can worsen over time. Half of the 2250 participants will get a new valve placed using a thin tube (TAVR), while the other half will be closely monitored with standard care. T…

This study follows 150 people with severe aortic stenosis who receive a new type of heart valve (Myval) through a minimally invasive procedure called TAVI. The goal is to see how safe and effective the valve is by tracking complications like death, stroke, or kidney injury. Parti…

This study is testing a new heart valve called Hydra for people with severe aortic stenosis, a condition where the heart's main valve is narrowed. Researchers will check how safe and effective the valve is up to one year after implantation in 250 patients. The goal is to see if t…

This study looks at whether giving an extra balloon inflation after placing a new heart valve (TAVI) helps the valve open more evenly and work better. About 146 people with severe aortic stenosis will be randomly assigned to receive this extra step or not. The goal is to see if i…

This study tests whether a daily pill called enavogliflozin (a type of SGLT2 inhibitor) can reduce the risk of major heart problems or worsening heart failure in people who have already had a valve replacement (TAVR) for severe aortic stenosis and still have heart failure with pr…

This study tests a new heart valve called the SAPIEN X4 in 200 people who have a failing artificial aortic valve and are at high risk for surgery. The goal is to see if the new valve is safe and works well. Participants will be followed to track outcomes like death, stroke, and q…

This study compares two types of replacement heart valves (Allegra and Sapien) in people whose surgically implanted aortic valve has stopped working properly. About 104 adults with symptoms like chest pain or shortness of breath will be randomly assigned to get one of the two val…

This study looks at how safe and effective a new heart valve called Hydra is for people with severe aortic stenosis (a narrowed heart valve). About 50 people will get the valve through a less invasive procedure called TAVI. Researchers will check their health for one year after t…

This study tests whether using remote monitoring devices after a minimally invasive heart valve procedure (TAVI) allows patients to safely go home the same day instead of staying in the hospital. About 216 adults will be randomly assigned to either standard care or a remote monit…

This study is checking how well a new version of a heart valve, the SAPIEN 3 Ultra RESILIA, works over time in 150 people with severe aortic stenosis. The valve has special features to prevent calcium buildup, which may help it last longer. Researchers will use heart ultrasounds …

This study compares two ways of managing blood thinners after a minimally invasive heart valve replacement (TAVI). Some patients will routinely receive a drug called protamine to reverse the blood thinner, while others will only get it if needed. The goal is to see if routine use…

This study tests a new device called GEMINUS for people with severe aortic stenosis, a condition where the heart's aortic valve is narrowed. The goal is to see if the device is safe and can be placed correctly. About 30 adults will get the new valve and be followed for up to 5 ye…

This study follows 550 people whose TAVI heart valve has stopped working properly. Researchers will track how well a second TAVI procedure works, including safety and long-term results. The goal is to help doctors decide the best way to treat patients with a failed TAVI valve.

This study is looking at how safe and effective a new device called the Hydra TAVI system is for people with severe aortic stenosis, a condition where the heart's aortic valve becomes narrow. Researchers will follow 500 patients who get the implant to track outcomes like heart-re…

This study tests a new way to treat people with severe aortic stenosis who also have heavily calcified leg arteries that normally block a less invasive heart valve replacement. Doctors use a special balloon that sends sound waves to crack the calcium, making room for the valve de…

This study tests if a newer, less invasive heart-lung machine (MiECC) causes fewer serious problems after heart surgery than the standard machine. About 1300 adults having planned coronary bypass or aortic valve replacement will be randomly assigned to one of the two machines. Th…

This study is tracking the safety and performance of a new, less invasive heart valve replacement device for people with severe aortic stenosis, a narrowing of the heart's main valve. It will follow 122 high-risk patients who are not good candidates for open-heart surgery. The ma…

This study tests whether giving iron through a vein can improve quality of life and walking ability in older adults who have iron deficiency and just had a heart valve replacement. About 402 participants will be randomly assigned to receive either iron infusions or standard care.…

This study compares two types of nerve blocks (PENG block and fascia iliaca block) to standard local anesthesia for pain control during a minimally invasive heart valve replacement called TAVI. Researchers will measure how much sedation patients need during the procedure and thei…

This study looks at 126 people getting a new heart valve (TAVR) to see if the type of sleep medicine they receive affects how well they feel the next day. Participants will be randomly assigned to one of three common sedatives and will fill out short surveys about pain, comfort, …

This study watches 150 adults who are getting heart valve procedures (TAVI or M-TEER) to see if their sleep breathing improves. Participants take a sleep test before the procedure and again 6 months later. The goal is to learn how fixing heart valves might help with sleep problem…

This study looks at whether placing a new heart valve without special alignment makes it easier for doctors to re-enter the coronary arteries later. About 100 people with severe aortic stenosis getting a TAVR will be randomly assigned to standard or aligned valve placement. The m…

This study looks at whether CT and echo scans taken before and after a TAVI heart valve procedure can help predict how the new valve will work over time. About 40 adults with severe aortic stenosis will get an extra CT scan six months after their procedure. The scan data will be …

This study uses a special PET-MR scan to measure a protein called HDAC in the heart. Researchers will compare HDAC levels in people with aortic stenosis or diabetes to those in healthy volunteers. The goal is to better understand how HDAC relates to heart disease. About 96 partic…

This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) in people with aortic valve stenosis. Researchers will use exercise MRI to measure how well each valve works during physical activity. The goal is to see which valve type provides be…

This study follows 10,000 adults with heart valve disease to understand how the condition progresses and what factors influence it. Researchers will use imaging tests like echocardiograms, CT scans, and MRIs, along with medical history and lifestyle information. The goal is to pr…

This study tests whether a structured shared decision-making process helps patients with severe aortic stenosis choose between two types of heart valve replacement (TAVR or SAVR). About 140 patients aged 70 and older will be randomly assigned to either the structured approach or …

This study uses a special MRI technique (4D Flow) to measure how well the left ventricle pumps blood in people with severe aortic valve narrowing who are scheduled for valve replacement. Researchers will develop computer models to automatically analyze heart images and compare th…

This study tests a new device called HemoCept that measures blood volume and heart efficiency during a procedure to replace a narrowed heart valve (TAVR). Researchers want to see if the device's readings match standard heart measurements. About 20 adults with aortic valve stenosi…

This study looks at 310 people who need a second heart valve replacement (valve-in-valve TAVR). It compares two methods—ultrasound (echo) versus a tube measurement (catheterization)—to see which gives a truer picture of how well the new valve works. The goal is to reduce complica…

This study will follow 2500 people who had a TAVR procedure (a less invasive way to replace a heart valve) to better understand their risks of bleeding or blood clots afterward. Researchers will track different blood thinner treatments and types of replacement valves to see how t…