Heart valve showdown: which replacement works best for failing surgical valves?

NCT ID NCT06049654

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 26 times

Summary

This study compares two types of replacement heart valves (Allegra and Sapien) in people whose surgically implanted aortic valve has stopped working properly. About 104 adults with symptoms like chest pain or shortness of breath will be randomly assigned to get one of the two valves. The goal is to see which valve does a better job at improving blood flow through the heart.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Freeman Hospital

    RECRUITING

    Newcastle, United Kingdom

  • Hospital Clinico San Carlos

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Clínico Universitario de Salamanca

    RECRUITING

    Salamanca, 37007, Spain

  • Hospital Universitari I Politècnic de La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitari de Bellvitge

    RECRUITING

    L'Hospitalet de Llobregat, 08907, Spain

  • Hospital Universitario Puerta De Hierro

    RECRUITING

    Majadahonda, 28222, Spain

  • Hospital Universitario de La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Manchester University NHS Foundation Trust

    RECRUITING

    Manchester, United Kingdom

  • Morriston Hospital, Swansea

    RECRUITING

    Swansea, United Kingdom

Conditions

Explore the condition pages connected to this study.