Heart valve showdown: which replacement works best for failed surgical valves?
NCT ID NCT06049654
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two different devices (Allegra and Sapien) used to replace a failing surgically implanted aortic heart valve without open-heart surgery. About 104 adults with a deteriorated biological aortic valve will be randomly assigned to get one of the two devices. The main goal is to see which device provides better blood flow through the new valve.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
transcatheter aortic valve implantation device (Allegra or Sapien)
What this could lead to
If successful, this could show which device is better for replacing a worn-out surgical aortic valve, improving heart function and symptoms.
What could go wrong
This is a relatively small trial (104 people) and only compares two specific devices. Results may not apply to all patients or other valves.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Azienda Ospedaliera di Perugia
RECRUITINGPerugia, Italy
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Azienda Ospedaliero- Universitaria di Alessandria
RECRUITINGAlessandria, Italy
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Freeman Hospital
RECRUITINGNewcastle, United Kingdom
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Hospital Clinico San Carlos
RECRUITINGMadrid, 28040, Spain
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Hospital Clínico Universitario de Salamanca
RECRUITINGSalamanca, 37007, Spain
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Hospital Universitari I Politècnic de La Fe
RECRUITINGValencia, 46026, Spain
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Hospital Universitari de Bellvitge
RECRUITINGL'Hospitalet de Llobregat, 08907, Spain
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Hospital Universitario Puerta De Hierro
RECRUITINGMajadahonda, 28222, Spain
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Hospital Universitario de La Paz
RECRUITINGMadrid, 28046, Spain
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Manchester University NHS Foundation Trust
RECRUITINGManchester, United Kingdom
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Morriston Hospital, Swansea
RECRUITINGSwansea, United Kingdom