AORTIC VALVE STENOSIS
Clinical trials for AORTIC VALVE STENOSIS explained in plain language.
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New heart valve tested in hundreds of patients shows promise for safer treatment
Disease control CompletedThis study tested the Evolut PRO system, a replacement heart valve, in 638 patients with severe aortic valve stenosis who were at high or intermediate risk for open-heart surgery. The goal was to see how safe and effective the valve is in real-world hospital settings over five ye…
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: Medtronic Cardiovascular • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Race against time: new program aims to slash heart valve surgery waits
Disease control CompletedThis study tested a program designed to reduce the waiting time for a critical heart valve procedure called TAVI. It combined online patient education tools with changes to hospital coordination. The goal was to see if this approach could get more patients their needed treatment …
Matched conditions: AORTIC VALVE STENOSIS
Phase: NA • Sponsor: University Hospital, Rouen • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Heart valve replacement study skips a step, aims for fewer complications
Disease control CompletedThis study compared two ways to implant a replacement aortic valve in people with a dangerously narrowed valve who are at high risk for open-heart surgery. Researchers tested if implanting the new valve directly was as successful and safe as the standard method, which first uses …
Matched conditions: AORTIC VALVE STENOSIS
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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Computer alerts aim to stop doctors missing Life-Saving heart valve treatments
Disease control CompletedThis study tested whether automated alerts sent to doctors could help identify and treat patients with severe aortic stenosis or mitral regurgitation—two serious heart valve conditions. Over 2,100 patients were involved to see if these alerts led to more timely specialist visits …
Matched conditions: AORTIC VALVE STENOSIS
Phase: NA • Sponsor: Tempus AI • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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New nerve block aims to ease pain after minimally invasive heart surgery
Symptom relief CompletedThis study tested whether a targeted nerve block, guided by ultrasound, could help manage pain in patients undergoing a minimally invasive heart valve replacement (TAVI). Researchers compared pain levels and the need for strong painkillers in 40 patients who either received the n…
Matched conditions: AORTIC VALVE STENOSIS
Phase: NA • Sponsor: Medipol University • Aim: Symptom relief
Last updated Apr 01, 2026 14:42 UTC
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Nerve block tested to ease pain in keyhole heart surgery
Symptom relief CompletedThis study tested if a targeted nerve block in the abdomen could better control pain for patients undergoing a minimally invasive heart valve replacement (TAVI). The goal was to keep patients more comfortable and still during the procedure, which may improve safety and satisfacti…
Matched conditions: AORTIC VALVE STENOSIS
Phase: NA • Sponsor: Istanbul University - Cerrahpasa • Aim: Symptom relief
Last updated Mar 31, 2026 12:11 UTC
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Heart scans vs. biopsies: researchers seek better fibrosis detection
Knowledge-focused CompletedThis completed study aimed to understand how well standard heart ultrasound (echocardiography) can detect heart muscle scarring (fibrosis) in patients with severe aortic valve narrowing. Researchers analyzed existing data from 22 patients who had both ultrasound scans and small t…
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:43 UTC
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New heart scans aim to predict who does best after valve procedure
Knowledge-focused CompletedThis study tested whether two advanced heart scan techniques could better predict how patients do after a TAVI procedure to replace a narrowed aortic valve. Researchers followed 100 patients with severe aortic stenosis to see if these scans could more accurately forecast risks li…
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: Damanhour University • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:42 UTC
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Can fixing a stiff heart valve heal the heart's scars?
Knowledge-focused CompletedThis study looked at whether replacing a severely narrowed heart valve (aortic stenosis) could reduce scarring in the heart muscle. Researchers followed 86 patients, using special heart MRI scans before and one year after their valve replacement surgery. The goal was to see if th…
Matched conditions: AORTIC VALVE STENOSIS
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Doctors measure heart 'Stiffness' during surgery to understand valve disease
Knowledge-focused CompletedThis study aimed to understand how aortic valve stenosis affects heart muscle stiffness. Researchers measured stiffness directly on the heart during surgery in 98 patients—some having valve replacement and others having bypass surgery. They used a special ultrasound technique to …
Matched conditions: AORTIC VALVE STENOSIS
Phase: NA • Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Mar 09, 2026 14:23 UTC