Heart valve mismatch mystery: does it really matter after surgery?

NCT ID NCT00854698

Completed Knowledge-focused Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 77 patients under 60 who had a mechanical aortic valve replacement to see if a mismatch between the valve size and the patient's body affects heart recovery and exercise ability. Participants did exercise tests and heart ultrasounds years after surgery. The goal is to settle a debate about whether valve mismatch truly impacts long-term heart function and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exercise training
What this could lead to: If successful, this could clarify whether aortic valve mismatch after replacement truly limits exercise capacity and heart recovery, guiding future treatment decisions.
What could go wrong: This is a small, completed observational study with only 77 participants, so results may not apply to all patients. It does not test a new treatment, so no direct benefit is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

THE LEFT VENTRICULAR REMODELING AFTER MECHANICAL AORTIC VALVE REPLACEMENT

Contacts and locations

Locations

CHRU, Nouvel Hôpital Civil, Service de chirurgie cardio-vasculaire

Strasbourg, France

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