Routine protamine after TAVI may cut bleeding risk

NCT ID NCT05774691

First seen Nov 01, 2025 · Last updated Jun 11, 2026 · Updated 39 times

Summary

This study compared giving protamine routinely to all patients after TAVI versus giving it only when needed. The goal was to see if routine use lowers the chance of death or major bleeding within 30 days. About 1000 adults undergoing TAVI took part. The approach aims to improve safety after heart valve replacement.

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Contacts and locations

Locations

  • A.S.Z. Aalst

    Aalst, Belgium

  • Amsterdam University Medical Center

    Amsterdam, Netherlands

  • Leiden University Medical Center

    Leiden, South Holland, Netherlands

  • Maastricht UMC

    Maastricht, Limburg, Netherlands

  • St. Antonius Hospital

    Nieuwegein, Utrecht, Netherlands

  • University Hospitals Leuven

    Leuven, Belgium

Conditions

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