AORTIC VALVE STENOSIS

This study tested a less invasive procedure called TAVR against traditional open-heart surgery for replacing a severely narrowed aortic valve. It involved over 2,200 patients who were considered at low risk for complications from surgery. The main goal was to see if the TAVR proc…

This study is testing whether a medication called icosapent ethyl can slow the progression of aortic valve stenosis, a condition where the heart's main valve narrows. It will involve about 110 adults over 50 with mild to moderate disease. The main goal is to see if the treatment …

This trial is comparing two different types of replacement heart valves for people with a severely narrowed aortic valve and a small aortic root. Over 1,100 participants were randomly assigned to receive either a self-expanding valve or a balloon-expandable valve. The main goal i…

This study is testing a new device called the Navitor valve, which is designed to replace a narrowed aortic heart valve without major open-heart surgery. It will enroll about 1,500 people with severe, symptomatic aortic stenosis who are considered at low or intermediate risk for …

This study is testing whether colchicine, an anti-inflammatory medication, can slow the progression of aortic valve stenosis—a serious heart condition where the main heart valve narrows. Researchers are enrolling 150 patients with moderate but symptom-free valve narrowing to see …

This early study aimed to test the safety and performance of a new device called the Leaflex Performer. It was designed for patients with severe, symptomatic aortic valve stenosis who were not yet recommended for a full valve replacement. The goal was to see if the device could i…

This study is a registry that tracks 900 patients who have had one of two procedures to replace a narrowed aortic heart valve. It aims to compare the long-term safety and effectiveness of traditional open-heart surgery versus a newer, less invasive catheter-based procedure. The r…

This study is testing whether it is safe and effective for patients to be discharged from the hospital just 24 hours after a TAVI procedure, a minimally invasive heart valve replacement. It involves 585 adults with aortic valve disease who are having the procedure done through th…

This study is testing if performing heart valve replacement surgery earlier than current guidelines recommend can improve outcomes for patients with severe aortic stenosis. It focuses on patients who have no symptoms but show early signs of heart muscle scarring on an MRI scan. T…

This study aims to see if two newer types of self-expanding heart valves work as well as each other, and if a simpler, 'minimalist' procedure is as safe and effective as the standard approach. It involves 836 adults with severe, symptomatic aortic valve stenosis who need a valve …

This study is testing whether a medication called empagliflozin helps the heart recover better after surgery to replace a narrowed aortic valve. About 205 patients who have this surgery will receive either the real drug or a placebo pill for six months. Researchers will check if …

This study aims to find out which of two common types of heart valve implants is better for people with severe, symptomatic aortic stenosis. It will compare a balloon-expandable valve to a self-expanding valve in nearly 2,000 patients. The main goal is to see which valve leads to…

This study is testing the safety and performance of a new, less invasive heart valve replacement system. It is for people with severe, symptomatic aortic stenosis who are at intermediate risk for traditional open-heart surgery. The goal is to see if this new device can effectivel…

This study tests whether wearing a heart monitor for one week before a minimally invasive aortic valve replacement helps doctors spot hidden heart rhythm problems. Researchers want to see if finding these rhythm issues early allows for better treatment planning before the procedu…

This study is testing if a smartphone app can detect a serious heart valve condition called aortic stenosis. Researchers are using the phone's microphone to record heart sounds from 100 people, half with the condition and half without. They will use artificial intelligence to see…

This study was withdrawn before any participants were enrolled. It planned to examine a specific protein (SGLT2) in heart tissue samples from patients undergoing surgery for a narrowed heart valve. The goal was to compare protein levels in patients with and without heart failure …

This study is observing how well aortic valve replacement surgery works and how safe it is for patients in everyday hospital settings. It is following 900 adults who have had the surgery to track their health outcomes, including survival and complications, for up to five years. T…

This study aims to understand if high levels of a specific blood fat called lipoprotein(a) cause a narrowed heart valve (aortic stenosis) to worsen faster. Researchers are comparing the progression of the valve disease over time in 364 patients who have either high or low levels …

This study aims to understand how heart rhythms change after a common, minimally invasive procedure to replace a narrowed heart valve. Researchers are looking back at data from 1000 patients to see who develops irregular heartbeats, when they happen, and what factors might predic…