AORTIC VALVE STENOSIS

This study tests a new heart valve device (Navitor TAVI) for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. It includes 1,500 participants who are at low or intermediate risk for surgery. The goal is to see if the device is safe and e…

This study compares two ways to replace a narrowed heart valve: a less invasive procedure (TAVI) and open-heart surgery (SAVR). About 1,400 people with severe aortic stenosis and intermediate surgical risk are being followed for up to 5 years. The main goal is to see if TAVI is a…

This study tests a less invasive procedure called TAVR against traditional open-heart surgery for people with severe aortic stenosis who are at low risk for surgery. About 2,200 participants will be followed for two years to see if TAVR is as safe and effective as surgery in prev…

This study was designed to test a new device called Leaflex Performer for people with severe aortic stenosis, a condition where the heart's aortic valve becomes narrowed. The goal was to see if the device could safely improve valve function without major surgery. However, the stu…

This study looks at people with severe aortic stenosis (a narrowed heart valve) who don't have symptoms yet. Doctors use MRI scans to find early heart muscle scarring, which can predict future problems. Participants with scarring are randomly assigned to either early valve replac…

This study compares two newer types of self-expanding heart valves and a simpler, less invasive procedure (minimalist approach) against standard care for people with severe aortic valve stenosis. About 836 participants will be randomly assigned to receive either a newer valve or …

This study tests whether icosapent ethyl, a purified fish oil medication, can slow the buildup of calcium in the aortic valve of people with mild-to-moderate aortic valve stenosis. About 110 adults over age 50 will take the drug and have their valve calcium levels measured over t…

This study looks at how well the SAPIEN 3 Ultra heart valve works in 200 people with severe, symptomatic aortic stenosis who are at intermediate or higher risk for open-heart surgery. Researchers are checking if the valve works as intended and tracking safety issues like stroke, …

This study tests a new heart valve device (CENTERA THV) in 101 people with severe aortic stenosis who are at intermediate risk for surgery. The valve is placed without open-heart surgery. The main goal is to see if it is safe and works well. This is not a cure, but aims to contro…

This study tests whether colchicine, an anti-inflammatory drug, can slow the progression of aortic valve stenosis—a common heart valve disease that currently has no medication. About 150 adults with moderate, symptom-free valve narrowing will take colchicine and be monitored with…

This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) in over 1,100 people with severe aortic stenosis and a small aortic valve. The goal is to see which valve performs better in terms of safety, function, and reducing complications lik…

This study compares two types of replacement heart valves placed through a thin tube (TAVI) in people whose surgically implanted aortic valves are small (23mm or less) and no longer working well. The goal is to see which device leads to fewer problems like high pressure across th…

This study tests whether empagliflozin, a drug used for diabetes, can help the heart recover better after aortic valve replacement. About 205 adults with severe aortic stenosis will receive either the drug or a placebo for 6 months after their procedure. The main goal is to see i…

This study compares two types of replacement heart valves used in a procedure called TAVI for people with a narrowed aortic valve. About 1,960 participants will be randomly assigned to receive either a balloon-expandable or self-expanding valve. The goal is to see which design le…

This study tests whether a smartphone app can detect severe aortic stenosis, a common heart valve condition, by using the phone's microphone and machine learning. Researchers will compare the app's accuracy to standard echocardiography in 100 adults. If successful, this could pro…

This study looks at whether it is safe for people with narrowed heart valves to be discharged just 24 hours after a minimally invasive valve replacement (TAVI). Researchers will track 585 patients for complications like stroke, heart attack, or need for a pacemaker. The goal is t…

This study looks at people with severe aortic stenosis who are scheduled for a TAVI procedure. Researchers use a portable heart monitor for at least a week before the procedure to find hidden heart rhythm problems that might otherwise go unnoticed. The goal is to see if catching …

This study looks at why aortic stenosis (a narrowing of the heart's aortic valve) gets worse over time. Researchers want to see if certain blood markers and special ultrasound patterns can predict faster disease progression. The goal is to find new targets for medicines that coul…

This study looks at 364 people with mild to moderate aortic valve stenosis, a condition where the heart's aortic valve narrows. Researchers compare those with high levels of lipoprotein(a) (a type of fat in the blood) to those with low levels, to see if the valve disease gets wor…

This study follows 1000 patients with severe aortic stenosis who received a new heart valve through a tube (TAVR). Researchers track heart rhythm changes over time using EKGs and monitors to understand how the procedure affects electrical signals in the heart. The goal is to iden…

This study followed 900 adults who had aortic valve replacement to see how safe and effective the procedure is in routine care. Researchers tracked deaths from any cause and heart-related deaths. The goal is to understand real-world outcomes beyond controlled trials.

This study was designed to measure a protein called SGLT2 in heart muscle samples from people with aortic valve stenosis. Researchers planned to compare those with and without diastolic heart failure to understand how gliflozine drugs might benefit the heart. The study was withdr…

This study is a registry that follows 900 people who had either surgical or catheter-based aortic valve replacement for aortic stenosis. The goal is to track long-term outcomes like death, heart attack, and stroke. It does not test a new treatment but collects real-world data to …