Heart valve showdown: which TAVI design saves more lives?
NCT ID NCT05454150
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial compares two types of replacement heart valves used in a procedure called TAVI for people with a narrowed aortic valve. One valve expands with a balloon, the other expands on its own. The study will track about 1,960 patients to see which valve leads to fewer deaths or strokes within 90 days and one year. The goal is to find out if one design is clearly better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
balloon-expandable valve (Sapien 3/Ultra) or self-expanding valve (Evolut R/Pro)
What this could lead to
If it works, this could show which valve design is safer and more effective for treating aortic stenosis, potentially changing standard practice.
What could go wrong
This is a large but early-stage comparison; results may not show a clear winner, and individual patient factors could still influence outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AP-HP Hôpitaux Universitaires Henri Mondor
Créteil, France
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AP-HP Hôpitaux Universitaires Pitié Salpêtrière
Paris, France
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CH Annecy Genevois
Annecy, France
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CHU Reims - Hôpitam Robert Debré
Reims, France
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CHU de Besançon
Besançon, France
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CHU de Bordeaux Hôpital Pellegrin
Pessac, France
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CHU de Caen
Caen, France
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CHU de Clermont-Ferrand
Clermont-Ferrand, France
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CHU de Grenoble
Grenoble, France
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CHU de Montpellier
Montpellier, France
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CHU de Nantes - Hôpital Laennec
Saint-Herblain, France
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CHU de Nîmes
Nîmes, France
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CHU de Saint-Etienne
Saint-Etienne, France
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CHU de Strasbourg
Strasbourg, France
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CHU de Toulouse
Toulouse, France
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CHU de Tours
Tours, France
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Centre Médico Chirurgical Arnault Tzanck
Saint-Laurent-du-Var, France
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Hôpital Privé Saint-Martin
Caen, France
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Institut Cardiovasculaire Paris Sud
Massy, France
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Institut Mutualiste Montsouris
Paris, France
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Médipôle Lyon Villeurbanne
Villeurbanne, France