Could botox in the heart stop Post-Surgery AFib?

NCT ID NCT04075981

Ongoing Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo injection. The main goal is to see if Botox reduces AFib episodes in the first three weeks after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Botulinum toxin type A (Xeomin)
What this could lead to: If it works, this could offer a new way to prevent a common and serious heart rhythm complication after cardiac surgery.
What could go wrong: This is a single Phase 3 trial with 220 participants. The effect may be modest or not better than placebo, and risks from injecting a neurotoxin near the heart are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aneurysm or dilatation of ascending aorta aortic valve insufficiency aortic valve stenosis coronary artery disorder atrial fibrillation prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC SURGERY

Contacts and locations

Locations

CHU Limoges

Limoges, France, France
Clinique Ambroise Paré

Neuilly-sur-Seine, Île-de-France Region, 92200, France
Corentin Celton

Issy-les-Moulineaux, France, France
Hôpital Européen Georges Pompidou

Paris, Île-de-France Region, 75015, France
Hôpital Marie Lannelongue

Le Plessis-Robinson, France, France
Hôpital Saint-Joseph

Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France
Institut Mutualiste Montsouris

Paris, Île-de-France Region, 75014, France

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