Could botox in the heart stop Post-Surgery AFib?
NCT ID NCT04075981
First seen Jul 01, 2026 · Last updated Jul 01, 2026
Summary
This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo injection. The main goal is to see if Botox reduces AFib episodes in the first three weeks after surgery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Botulinum toxin type A (Xeomin)
What this could lead to
If it works, this could offer a new way to prevent a common and serious heart rhythm complication after cardiac surgery.
What could go wrong
This is a single Phase 3 trial with 220 participants. The effect may be modest or not better than placebo, and risks from injecting a neurotoxin near the heart are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Limoges
Limoges, France, France
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Clinique Ambroise Paré
Neuilly-sur-Seine, Île-de-France Region, 92200, France
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Corentin Celton
Issy-les-Moulineaux, France, France
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Hôpital Européen Georges Pompidou
Paris, Île-de-France Region, 75015, France
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Hôpital Marie Lannelongue
Le Plessis-Robinson, France, France
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Hôpital Saint-Joseph
Marseille, Provence-Alpes-Côte d'Azur Region, 13008, France
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Institut Mutualiste Montsouris
Paris, Île-de-France Region, 75014, France