Common arthritis drug could be first pill for deadly heart valve disease

NCT ID NCT05162742

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 33 times

Summary

This study tests whether colchicine, an anti-inflammatory drug, can slow the progression of aortic valve stenosis—a common heart valve disease that currently has no medication. About 150 adults with moderate, symptom-free valve narrowing will take colchicine and be monitored with scans and echocardiograms. If successful, this could become the first drug therapy for millions of people with this condition, potentially delaying or avoiding the need for valve replacement surgery.

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Contacts and locations

Locations

  • Radboudumc

    Nijmegen, The Netherlands, Netherlands

Conditions

Explore the condition pages connected to this study.