Could a common gout drug save hearts? colchicine trial targets valve disease
NCT ID NCT05162742
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 3 trial tests whether colchicine, an anti-inflammatory drug, can slow the progression of aortic valve stenosis—a narrowing of the heart's aortic valve that currently has no drug treatment. The study enrolls 150 people with moderate, symptom-free valve disease. Participants receive either colchicine or a placebo for up to 2 years, and researchers track changes in valve calcium buildup and other measures. If successful, colchicine could become the first medical therapy for this condition.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- colchicine
- What this could lead to
- If it works, this could be the first drug to slow aortic valve stenosis, potentially delaying or avoiding the need for valve replacement surgery.
- What could go wrong
- This is a relatively small phase 3 trial (150 people) testing a drug already used for other conditions. The effect may be modest or not significant, and colchicine can cause side effects like stomach upset.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for AORTIC VALVE CALCIFICATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Radboudumc
Nijmegen, The Netherlands, Netherlands
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can better healthcare access save hearts after prison?
- Could a gentle yoga practice turn down the Body's pain and inflammation?
- Can lifestyle choices after a stroke extend life and prevent a second one?
- Could a simple health chat slash heart disease and cancer risk?
- Could a stress hormone be behind the hidden danger of low blood sugar?
- One scan, many answers: can a new CT predict heart risks after stenting?