Heart valve showdown: which measurement method wins for TAVR patients?

NCT ID NCT05459233

Recruiting now Knowledge-focused Sponsor: Institut universitaire de cardiologie et de pneumologie de Québec, University Laval Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two methods—ultrasound (echocardiography) versus direct pressure measurements (catheterization)—to guide additional balloon inflation after valve-in-valve TAVR. About 310 people with failing surgical aortic valves will be randomly assigned to one method. The goal is to see which approach leads to better valve function, fewer complications, and improved quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAPIEN 3 Ultra valve
What this could lead to: If successful, this could show that using catheter measurements leads to better valve performance and fewer complications after valve-in-valve TAVR.
What could go wrong: This is a mid-sized trial comparing two measurement techniques, not testing a new treatment. The results may not change current practice if the differences are small.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve insufficiency aortic valve stenosis Prosthesis Failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE REGURGITATION AORTIC VALVE STENOSIS PROSTHESIS FAILURE

Contacts and locations

Locations

IUCPQ
RECRUITING

Québec, Quebec, G1V 4G5, Canada
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
South Broward Hospital Disctrict D/B/A Memorial Healthcare System
RECRUITING

Hollywood, Florida, 33021, United States
St-Joseph's Health INC
NOT_YET_RECRUITING

Syracuse, New York, 13203, United States
The Christ Hospital Health Network
RECRUITING

Cincinnati, Ohio, 45219, United States
University of California
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
William Beaumont Hospital
RECRUITING

Royal Oak, Michigan, 48073, United States

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