New heart valve offers hope for High-Risk patients with failing artificial valves
NCT ID NCT05172973
First seen Jan 11, 2026 · Last updated May 16, 2026 · Updated 16 times
Summary
This study tests a new heart valve called the SAPIEN X4 in 200 people who have a failing artificial aortic valve and are at high risk for surgery. The goal is to see if the new valve is safe and works well. Participants will be followed to track outcomes like death, stroke, and quality of life.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alexian Brothers Hospital Network
RECRUITINGLisle, Illinois, 60532, United States
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Atlantic Health System Morristown
RECRUITINGMorristown, New Jersey, 07960, United States
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Bay Area Structural Heart at Sutter Health
RECRUITINGSan Francisco, California, 94105, United States
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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Cardiovascular Research Institute of Kansas
RECRUITINGWichita, Kansas, 67226, United States
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Carolinas Health System
RECRUITINGCharlotte, North Carolina, 28204, United States
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Columbia University Medical Center / NYPH
RECRUITINGNew York, New York, 10032, United States
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Cornelll University New York
RECRUITINGNew York, New York, 10021, United States
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Emory University Atlanta
RECRUITINGAtlanta, Georgia, 30308, United States
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Hamilton Health Sciences
RECRUITINGHamilton, Ontario, L8L 2X2, Canada
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Henry Ford Hospital Detroit
RECRUITINGDetroit, Michigan, 48202, United States
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Hoag Memorial Hospital Presbyterian
RECRUITINGNewport Beach, California, 92663, United States
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Institut Universitaire de Cardiologie et de Pneumologie de Québec- Universite Laval
RECRUITINGQuébec, G1V4G5, Canada
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Kaiser San Francisco
RECRUITINGSan Francisco, California, 94115, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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MedStar Union Memorial Hospital
RECRUITINGBaltimore, Maryland, 21218, United States
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Naples Community Hospital Healthcare System
RECRUITINGNaples, Florida, 34102, United States
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Northwestern University Chicago
RECRUITINGEvanston, Illinois, 60208, United States
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Novant Health and Vascular Institute
RECRUITINGCharlotte, North Carolina, 28204, United States
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Oklahoma Heart Institute
RECRUITINGTulsa, Oklahoma, 74104, United States
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Piedmont Heart Institute
RECRUITINGAtlanta, Georgia, 30309, United States
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Robert Wood Johnson University Hospital
RECRUITINGNew Brunswick, New Jersey, 08901, United States
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Rochester General Hospital
RECRUITINGRochester, New York, 14621, United States
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Saint Thomas Health
RECRUITINGNashville, Tennessee, 37205, United States
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St. Paul's Hospital Vancouver
RECRUITINGVancouver, British Columbia, V6Z1Y6, Canada
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Stanford University Medical Center
RECRUITINGStanford, California, 94305, United States
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The Christ Hospital
RECRUITINGCincinnati, Ohio, 45219, United States
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The Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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The Heart Hospital Baylor Plano
RECRUITINGPlano, Texas, 75093, United States
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The Valley Hospital
RECRUITINGRidgewood, New Jersey, 07450, United States
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UC Health Medical Center of the Rockies
RECRUITINGLoveland, Colorado, 80538, United States
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University of Buffalo
RECRUITINGBuffalo, New York, 14203, United States
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University of Texas Memorial Hermann
RECRUITINGHouston, Texas, 77030, United States
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University of Washington Seattle
WITHDRAWNSeattle, Washington, 98195, United States
Conditions
Explore the condition pages connected to this study.