Erasmus Medical Center

This trial investigates whether adding secretin—a hormone that helps produce bicarbonate—during machine perfusion of donor livers can restore the protective 'bicarbonate umbrella' in bile ducts. Researchers will treat up to 20 donor livers with secretin while they are kept on a m…

This early-stage trial tests a therapeutic vaccine called ISA104 in 24 people with chronic hepatitis B who are already on antiviral drugs. The goal is to see if the vaccine is safe and can boost the immune system to better fight the virus. Participants will receive either ISA104 …

This study tests whether giving chemotherapy both before and after surgery helps people with pancreatic cancer live longer compared to chemotherapy only after surgery. About 378 patients with resectable pancreatic cancer will be randomly assigned to one of two treatment schedules…

This study evaluates 12 different healthy lifestyle programs for children aged 4 to 12 who are overweight. About 1,000 kids and their parents will take part in activities like sports, nutrition advice, and behavior coaching. Researchers will measure changes in quality of life, BM…

This study tests whether giving a special nutrient mixture (Olimel N12) during hemodialysis can help prevent muscle loss and improve quality of life in people with end-stage kidney disease. About 166 patients will receive either the nutrient infusion or a simple glucose solution …

This study tests whether taking potassium supplements can slow down kidney function loss in people with moderate-to-severe chronic kidney disease (CKD) and high blood pressure. About 532 adults with CKD stage 3b or 4 will receive potassium or a placebo. The goal is to see if pota…

This study looks at whether taking a daily multivitamin can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like tirzepatide) for weight loss. About 246 adults with obesity who have been on a stable GLP-1 dose for at least 3 months will be randomly assigned …

This study tests whether waiting to clamp the umbilical cord until after the baby's lungs have filled with air can reduce dangerous lung blood pressure (pulmonary hypertension) in newborns with congenital diaphragmatic hernia (CDH). About 140 infants with left-sided CDH will be r…

This study tests a computer dashboard that helps doctors and nurses in the Neonatal Intensive Care Unit (NICU) manage pain in newborn babies. The dashboard shows real-time data to flag when a baby may be in discomfort. Researchers will compare pain levels in 1,250 babies before a…

This study follows 90 living liver donors to see how much their liver regrows within a year after donation. Researchers will use CT or MRI scans to measure liver volume and look for factors like age, sex, and weight that might influence regrowth. The goal is to better understand …

This study looks at whether a special MRI scan (MRCP) can accurately measure liver fat in people who want to donate part of their liver. Currently, donors need a liver biopsy, which is invasive and carries risks. The researchers will compare MRCP results with biopsy results from …