Could a hormone shield bile ducts in transplanted livers?

NCT ID NCT07651748

ENROLLING_BY_INVITATION Disease control Sponsor: Erasmus Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether adding secretin—a hormone that helps produce bicarbonate—during machine perfusion of donor livers can restore the protective 'bicarbonate umbrella' in bile ducts. Researchers will treat up to 20 donor livers with secretin while they are kept on a machine that pumps blood-like fluid through them. The goal is to see if this improves bile duct health and helps doctors decide which livers are safe to transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: synthetic human secretin
What this could lead to: If it works, this could help more donor livers pass viability checks and reduce bile duct complications after transplantation.
What could go wrong: This is a small early-phase trial with only 20 livers, so results may not apply broadly. The therapy is experimental and may not improve outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER TRANSPLANTATION

Contacts and locations

Locations

Erasmus Medical Center

Rotterdam, South Holland, 3015 GD, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.