A new Anti-Rejection strategy may spare kidney function after liver transplant

NCT ID NCT07739914

Not yet recruiting Disease control Sponsor: Hannover Medical School Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This phase III trial is testing whether switching liver transplant recipients to an everolimus-based, calcineurin inhibitor-free regimen one year after surgery can better preserve kidney function compared to staying on a low-dose calcineurin inhibitor. The study enrolls 150 adults who received a liver transplant 12 to 36 months ago and are at low risk of rejection. Participants are randomly assigned to either the everolimus regimen or the standard low-dose calcineurin inhibitor regimen, and their kidney function is measured over 14 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: everolimus (an mTOR inhibitor) combined with mycophenolate mofetil, compared to low-dose tacrolimus or cyclosporine with or without low-dose mycophenolate mofetil
What this could lead to: If successful, this approach could help liver transplant recipients keep their new organ while reducing the long-term kidney damage caused by standard anti-rejection drugs.
What could go wrong: The trial is relatively small and only includes patients with a low risk of rejection, so results may not apply to everyone. There is also a risk that the drug switch could increase the chance of liver rejection.

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Conditions

The condition(s) this trial relates to.

hereditary sensory and autonomic neuropathy liver disorder Rejection, Psychology

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER ALLOGRAFT LIVER DISEASES LIVER TRANSPLANTATION

Contacts and locations

Locations

Charité - University Hospital Berlin; Department of Surgery

Berlin, State of Berlin, 13353, Germany
Medical School Hannover, Department of Gastroenterology, Hepatology, Endocrinology and Infectious Diseases

Hanover, Lower Saxony, 30625, Germany
Otto von Guericke University Magdeburg, Department of Visceral, Vascular, and Transplant Medicine

Magdeburg, Saxony-Anhalt, 39120, Germany
RWTH Aachen University Hospital, Clinic for Gastroenterology, Metabolic Disorders, and Internal Intensive Medicine (Medical Clinic III)

Aachen, North Rhine-Westphalia, 52074, Germany
Schleswig-Holstein University Hospital (UKSH), Department of General, Visceral, Thoracic, Transplant, and Pediatric Surgery, Campus Kiel

Kiel, Schleswig-Holstein, 24105, Germany
University Hospital Bonn, Department of General, Visceral, Transplant, and Vascular Surgery

Bonn, North Rhine-Westphalia, 53105, Germany
University Hospital Essen, Department of Gastroenterology, Hepatology, and Transplant Medicine

Essen, North Rhine-Westphalia, 45147, Germany
University Hospital Heidelberg; Department of Internal Medicine IV

Heidelberg, Baden-Wurttemberg, 69120, Germany
University Hospital Jena, Department of General, Visceral, and Vascular Surgery

Jena, Thuringia, 07747, Germany
University Hospital Münster, Department of Internal Medicine B Gastroenterology, Hepatology, Endocrinology, Clinical Infectious Diseases

Münster, North Rhine-Westphalia, 48149, Germany
University Hospital Regensburg, Department of Surgery

Regensburg, Bavaria, 93053, Germany
University Hospital Tübingen, Department of Internal Medicine I

Tübingen, Baden-Wurttemberg, 72076, Germany
University Hospital Würzburg, Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery

Würzburg, Bavaria, 97080, Germany
University Medical Center Hamburg, I. Department of Medicine, Department of Hepatobiliary and Transplantation Surgery

Hamburg, Free and Hanseatic City of Hamburg, 20246, Germany
University Medical Center Rostock, Interdisciplinary Transplant Center, Department of General, Visceral, Thoracic, Vascular, and Transplant Surgery

Rostock, Mecklenburg-Vorpommern, 18057, Germany
University Medical Center of Johannes Gutenberg University Mainz, Department of Internal Medicine I

Mainz, Rhineland-Palatinate, 55131, Germany

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