Can a quick MRI scan reveal what a healthy Child's liver looks like?
NCT ID NCT03235414
First seen Jul 24, 2026 ยท Last updated Jul 24, 2026
Summary
This study aims to determine normal liver stiffness values in healthy children aged 7 to 17 using a special MRI technique called MR elastography. Participants receive a one-time research MRI and a blood draw to confirm their liver is healthy. The results could help doctors better diagnose liver disease in children by providing a baseline of what is normal.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could provide a reference range of healthy liver stiffness in children, improving non-invasive diagnosis of liver diseases.
- What could go wrong
- This is an observational study in healthy volunteers, so it does not test a treatment. Results may vary across MRI machines and field strengths, limiting generalizability.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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101 people
The number who actually took part.
- Started
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Feb 2018
- Finished
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Jul 2020
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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7 to 17 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 7-17 years * No documented history of liver diseases * English speaking Exclusion Criteria: * NPO less than 4 hours * Body mass index \<10th or \> 85th percentile for age * Documented history of liver disease * Pregnancy * Inability to lie still for duration of the MRI * Inability to breath hold for the duration of the 15-20 second MR elastography sequence * Standard contraindication to MRI (implanted hardware, etc.) * Requirement of sedation or general anesthesia for MRI * Abnormality of any measured liver function test * Liver fat fraction \>5% by MRI PDFF
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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