LIVER DISEASES

This study is testing whether a specific injection can help protect the liver from damage during and after surgery to remove part of the liver for cancer. Researchers will compare two groups: one receives the liver-protecting injection before surgery and a combination of injectio…

This study is testing a new telehealth program designed to improve care for Veterans with advanced liver disease. A nurse counselor will work with 450 Veterans via video calls to help them understand their illness, identify their personal health goals, and make sure their treatme…

This early-stage trial is testing whether specially designed mixtures of helpful gut bacteria are safe for people hospitalized with serious liver disease. Researchers want to see if these bacterial mixtures can restore a healthier gut environment, which is often damaged in liver …

This study aims to find out if liver transplants are a good option for patients with a severe, sudden worsening of their chronic liver disease, known as ACLF. It will compare survival rates and quality of life for 3,000 very sick patients who get a transplant to those who do not.…

This is the first study in people to test a new personalized cell therapy called RTX001 for advanced liver disease. The therapy is made by collecting a patient's own white blood cells, engineering them in a lab to potentially reduce liver scarring and inflammation, and then retur…

This study is testing a machine that keeps donated livers functioning outside the body, allowing doctors to assess their quality. The goal is to see if this process can safely increase the number of livers available for transplant, helping more patients get a transplant sooner. R…

This study is testing a new support program called the Transitional Liver Clinic (TLC) for people with serious liver disease who are leaving the hospital. The goal is to see if this extra care helps patients avoid being readmitted to the hospital, improves their quality of life, …

This study is testing whether a minimally invasive endoscopic procedure to reduce stomach size, combined with lifestyle changes, is better than lifestyle changes alone for treating a serious fatty liver disease called MASH in people with obesity. Researchers will compare the two …

This study is testing whether a smartphone app can help people with alcohol-related liver disease start and stay in treatment programs. The app provides information and helps match patients to treatment options they prefer. Researchers will see if using the app leads more people …

This study is testing a new, single-probe version of a FibroScan device used to check liver health. Researchers want to see if this simpler probe gives results as accurate and reliable as the current probes that come in different sizes. They will also check if patients find the n…

This study aims to understand how chronic liver diseases, like hepatitis and fatty liver, are connected to other health problems a person might have. Researchers will look back at the medical records of up to 15,000 patients from Tzu Chi hospitals to see how these conditions affe…

This study aims to understand the differences in liver inflammation between two types of fatty liver disease: simple fatty liver (NAFL) and the more serious form (NASH). Researchers will collect liver cells from 60 patients already scheduled for a liver biopsy, using a fine needl…

This study aims to test two scoring systems (PLEASE and M10S20) to predict which patients with advanced chronic liver disease are most likely to develop liver failure or liver cancer. Researchers will follow 600 hospitalized patients, comparing a new risk-based monitoring schedul…

This study aims to see if a special MRI scan that measures muscle health can help predict which liver disease patients are at higher risk for serious health problems or death. Researchers will add an 8-10 minute scan to the routine MRIs of 1,200 patients at the University of Chic…

This study collects one-time blood or saliva samples from children who previously participated in liver disease research. The goal is to build a DNA bank to help scientists understand what causes these rare liver conditions and identify potential targets for future treatments. Re…

This study aims to better understand primary sclerosing cholangitis (PSC), a rare disease that scars the liver's bile ducts. Researchers will observe 1,000 children and young adults (ages 2-25) who already have PSC, collecting health information, images, and samples over time. Th…