LIVER DISEASES

This study tests whether giving a drug called polyene phosphatidylcholine before and after laparoscopic liver surgery can reduce liver damage in people with liver cancer. About 96 adults will be split into two groups: one gets the drug combo, the other gets standard care. The mai…

This study tests a program where a nurse counselor works with Veterans who have serious liver disease to help them understand their illness, share what matters to them, and choose between treatments aimed at a cure (like a liver transplant) or comfort. The goal is to make sure ea…

This study looks at how well liver transplants work for people with severe acute-on-chronic liver failure (ACLF), a life-threatening condition. Researchers will track 3,000 adults with cirrhosis who are listed for a transplant to see who survives and how different transplant type…

This study tests a method called normothermic machine perfusion, which keeps donated livers working outside the body so doctors can check their quality. The goal is to safely use livers that were previously considered unsuitable, helping 186 people on the transplant waiting list …

This early-stage trial tests whether giving a mix of healthy gut bacteria (from donors) to people hospitalized with liver disease is safe and tolerable. The study involves 24 adults with liver failure or cirrhosis who have low levels of certain gut chemicals. Researchers will mon…

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests a new treatment called RTX001 for people with severe liver cirrhosis that has caused complications. RTX001 uses the patient's own immune cells (macrophages) that are modified in a lab to reduce inflammation and scarring in the liver. The trial will enroll 30 adul…

This study tests a transitional care clinic for people with advanced liver disease after they leave the hospital. The goal is to reduce 30-day readmissions and improve quality of life. About 1,000 adults with cirrhosis or alcoholic hepatitis will be randomly assigned to the clini…

This study looks at whether giving people with alcohol-related liver disease personalized options for alcohol treatment helps them actually start and stay in treatment. Researchers will also correct common misunderstandings about treatment. About 268 adults from University of Mic…

This study looks at whether too much iron in the body raises the risk of liver problems in people who had a stem cell transplant more than 10 years ago. About 500 adults will be checked with blood tests and a special liver scan. The goal is to find out if treating iron overload c…

This study collects a one-time blood or saliva sample from up to 2,230 people who have rare liver diseases and were in earlier research. The goal is to store their DNA for future studies on what causes these diseases, how they progress, and possible genetic factors. Participants …

This study is testing a new single probe for FibroScan, a device that checks liver stiffness. Researchers want to see if this one probe works as well as the two different probes currently used. About 309 adults with chronic liver disease will take part. The goal is to simplify th…

This study looks at medical records from 15,000 people with chronic liver diseases (like hepatitis, fatty liver, or cirrhosis) to understand how these conditions affect other body systems. Researchers will track new cases of liver cancer and serious liver complications over time.…

This study looks at whether a special MRI scan that measures muscle health and frailty can help predict serious outcomes like death or the need for a liver transplant in people with liver disease. Researchers will follow 1,200 patients who are already getting an MRI for routine c…

This study is testing two new scoring methods (PLEASE and M10S20) to predict serious liver problems like liver failure or liver cancer in 600 people with advanced chronic liver disease. Participants are split into two groups: one gets standard check-ups every 6 months, while the …

This study follows 1,000 children with primary sclerosing cholangitis (PSC), a rare liver disease that damages bile ducts. Researchers will collect medical data, DNA, and other samples to understand how PSC progresses and affects daily life. The goal is to identify factors that m…

This study looks at people who have had liver damage from prescription drugs or herbal supplements. Researchers will collect health information and use special scans to track liver health over time. The goal is to learn more about why these injuries happen and how they progress. …

This study aims to better understand why some people with fatty liver disease develop dangerous inflammation (NASH) while others do not. Researchers will collect liver cells from 60 adults using a special needle and analyze them with advanced techniques. The goal is to find new c…