Cure My Disease

Don't miss your cure!

 Log in / Sign up

Massive study aims to improve liver transplant decisions

NCT ID NCT04613921

Knowledge-focused Sponsor: European Foundation for Study of Chronic Liver Failure Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 3000 adults with severe liver failure who are being considered for a liver transplant. Researchers want to learn which patients benefit most from the procedure and how to improve survival. The goal is to better guide doctors in making this life-saving decision.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could clarify when liver transplants are most beneficial for severe liver failure patients, potentially saving more lives.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not apply to all patients or centers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Acute or subacute liver failure. Patients with hepatocellular carcinoma Subjects listed for transplantation other than liver or liver-kidney transplant. Subjects with previous liver transplantation. Vulnerable population. Pregnant and/or breastfeeding woman Patients with relevant comorbidities

Ages

18 to 80 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Male or female subject ≥18 years of age. 2\. Subjects with diagnosis of liver cirrhosis (based on clinical, laboratory, endoscopic, and ultrasonographic features or on histology). 3\. Subjects who have been hospitalized for acute decompensation of liver cirrhosis and referred to the transplant team: * Group 1: patients listed for liver transplantation with ACLF-2 or 3 at the time of listing or developing ACLF 2-3 while on the waiting list. * Group 2: patients listed for liver transplantation with decompensated cirrhosis without ACLF-2 or 3 and poor liver function (MELD\>20) at the time of listing. * Group 3: patients having ACLF-2 or 3, are assessed for inclusion in the waiting list, but are finally not listed for liver transplantation. 4\. Patients (or trusted person, family member or close relation if the patient is unable to express consent) who have been informed and signed their informed consent Inclusion criteria Exclusion Criteria: \-

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Acute-on-chronic liver failure are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Acute-On-Chronic Liver Failure cirrhosis of liver liver disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute-on-chronic liver failure Liver cirrhosis Liver diseases Liver transplant; complications

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    105 sites in 27 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHP Beaujon

    RECRUITING

    Clichy, France

  • APHP Henri Mondor

    RECRUITING

    Créteil, France

  • APHP Hôpitaux Universitaires Pitié Salpêtrière

    RECRUITING

    Paris, France

  • Amrita Institute of Medical Sciences

    RECRUITING

    Kochi, India

  • Aster CMI Hospital

    NOT_YET_RECRUITING

    Bengaluru, Karnataka, India

  • Auckland City Hospital- New Zealand Liver Transplant Unit

    SUSPENDED

    Auckland, New Zealand

  • Austin Hospital

    RECRUITING

    Heidelberg, Australia

  • Austral University Hospital

    RECRUITING

    Buenos Aires, Argentina

  • Baylor College of Medicine (Scott & White)

    NOT_YET_RECRUITING

    Dallas, Texas, 75246, United States

  • Baylor St. Luke's Medical Centre

    RECRUITING

    Houston, Texas, 77030, United States

  • CHU Montpellier-Hôpital Saint Eloi

    RECRUITING

    Montpellier, France

  • CHU Rennes, Hôpital De Pontchaillou

    RECRUITING

    Rennes, France

  • CUB Erasme Hospital

    RECRUITING

    Brussels, Belgium

  • Ca' Granda. Policlinico Milano

    RECRUITING

    Milan, Italy

  • Cedars-Sinai Comprehensive Transplant Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Charité University Hospital

    RECRUITING

    Berlin, Germany

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Dr.Rela Institute & Medical Centre

    RECRUITING

    Chennai, India

  • Erasmus MC University Medical Center

    RECRUITING

    Rotterdam, Netherlands

  • Fortis Hospital Noida, FEHI, FMRI

    NOT_YET_RECRUITING

    Gurugramam, India

  • Geneva University Hospital (HUG)

    NOT_YET_RECRUITING

    Geneva, Switzerland

  • Ghent University Hospital

    RECRUITING

    Ghent, Belgium

  • Global Hospital. Super speciality & transplant centre

    NOT_YET_RECRUITING

    Mumbai, India

  • Goethe University Clinic

    NOT_YET_RECRUITING

    Frankfurt, Germany

  • Hannover Medical School

    NOT_YET_RECRUITING

    Hanover, Germany

  • Hautepièrre Hospital, Service de Réanimation Médicale

    RECRUITING

    Strasbourg, France

  • Hiroshima University Hospital

    RECRUITING

    Hiroshima, Japan

  • Hospital Alemán

    RECRUITING

    Buenos Aires, Argentina

  • Hospital Clinic in Barcelona

    RECRUITING

    Barcelona, Spain

  • Hospital Curry Cabral

    RECRUITING

    Lisbon, Portugal

  • Hospital Marqués de Valdecilla

    RECRUITING

    Santander, Spain

  • Hospital Universitari i Politècnic La Fe

    RECRUITING

    Valencia, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, Spain

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, Spain

  • Hospital Universitario Virgen del Rocío

    RECRUITING

    Seville, Spain

  • Hospital Vall d'Hebron

    RECRUITING

    Barcelona, Spain

  • Hospital das Clínicas da Universidade de São Paulo

    RECRUITING

    São Paulo, Brazil

  • Hôpital Paul Brousse

    RECRUITING

    Villejuif, France

  • Hôpital de la Croix-Rousse

    RECRUITING

    Lyon, France

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029-5674, United States

  • Indraprastha Apollo Hospitals

    NOT_YET_RECRUITING

    New Delhi, National Capital Territory of Delhi, India

  • Inonu University, Liver Transplantation Institute

    RECRUITING

    Malatya, Anatolia, Turkey (Türkiye)

  • Institute for Clinical and Experimental Medicine

    NOT_YET_RECRUITING

    Prague, Czechia

  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

    RECRUITING

    Mexico City, Mexico

  • Irmandade Santa Casa de Misericórdia de Porto Alegre

    RECRUITING

    Porto Alegre, Brazil

  • Istanbul Memorial Bahcelievler Hospital

    SUSPENDED

    Istanbul, Turkey (Türkiye)

  • Italian Hospital in Buenos Aires

    RECRUITING

    Buenos Aires, Argentina

  • Jena University Hospital

    SUSPENDED

    Jena, Germany

  • Kaohsiung Chang Gung Memorial Hospital

    RECRUITING

    Kaohsiung City, Taiwan

  • Karolinska Institutet

    RECRUITING

    Stockholm, Stockholm County, 171 77, Sweden

  • Kasturba Hospital

    NOT_YET_RECRUITING

    Mumbai, Maharashtra, India

  • King's College Hospital

    RECRUITING

    London, United Kingdom

  • Kyoto University Hospital

    RECRUITING

    Kyoto, Japan

  • Kyushu University Hospital

    RECRUITING

    Fukuoka, Japan

  • LMU Großhadern

    SUSPENDED

    Munich, Germany

  • Leeds Teaching Hospitals NHS Trust

    RECRUITING

    Leeds, United Kingdom

  • Leipzig University Hospital

    NOT_YET_RECRUITING

    Leipzig, Germany

  • Mahatma Gandhi University of Medical Sciences and Technology

    NOT_YET_RECRUITING

    Jaipur, Rajasthan, India

  • Max Saket Hospital

    ACTIVE_NOT_RECRUITING

    New Delhi, India

  • Medanta Medicity

    NOT_YET_RECRUITING

    Gurugramam, India

  • Medical University of Vienna, Department of Transplant Surgery

    RECRUITING

    Vienna, Austria

  • Medical University of Warsaw, Dept. of General, Transplant & Liver Surgery

    RECRUITING

    Warsaw, Poland

  • Michael E DeBakey VA Medical Center

    NOT_YET_RECRUITING

    Houston, Texas, 77030-4211, United States

  • Montefiore Medical Center

    NOT_YET_RECRUITING

    New York, New York, 10467, United States

  • Nagasaki University Hospital

    RECRUITING

    Nagasaki, Japan

  • Niguarda Hospital

    RECRUITING

    Milan, Italy

  • Northwestern Memorial Hospital

    NOT_YET_RECRUITING

    Chicago, Illinois, 60611, United States

  • Ospedale Papa Giovanni XXIII-

    NOT_YET_RECRUITING

    Bergamo, Italy

  • Pablo Tobón Uribe Hospital

    RECRUITING

    Medellín, Colombia

  • Piedmont Healthcare

    RECRUITING

    Atlanta, Georgia, 30309, United States

  • Queen Elizabeth Hospital Birmingham

    RECRUITING

    Birmingham, United Kingdom

  • Queen Mary Hospital, The University of Hong Kong

    SUSPENDED

    Hong Kong, Hong Kong

  • Royal Free Hospital

    RECRUITING

    London, United Kingdom

  • Royal Prince Alfred Hospital

    RECRUITING

    Sydney, Australia

  • S.Orsola Hospital - Alma Mater Studiorum University of Bologna

    RECRUITING

    Bologna, Italy

  • Samsung Medical Center

    NOT_YET_RECRUITING

    Seoul, South Korea

  • Scottish Liver Transplant Unit, Royal Infirmary

    RECRUITING

    Edinburgh, United Kingdom

  • Seth GSMC & KEM Hospital

    NOT_YET_RECRUITING

    Mumbai, Maharashtra, India

  • Sir Charles Gairdner Hospital

    SUSPENDED

    Nedlands, Australia

  • Tampa General Hospital

    NOT_YET_RECRUITING

    Tampa, Florida, 33606, United States

  • The University of Chicago Medicine

    RECRUITING

    Chicago, Illinois, 60637, United States

  • Tokyo University Hospital

    RECRUITING

    Tokyo, Japan

  • Trousseau Hospital,

    RECRUITING

    Tours, France

  • UKM Muenster

    RECRUITING

    Münster, Germany

  • UZ Leuven

    RECRUITING

    Leuven, Belgium

  • University Hospital Aachen

    SUSPENDED

    Aachen, Germany

  • University Hospital Heidelberg

    NOT_YET_RECRUITING

    Heidelberg, Germany

  • University Hospital Mainz

    SUSPENDED

    Mainz, Germany

  • University Hospital Regensburg

    NOT_YET_RECRUITING

    Regensburg, Eastern Bavaria, Germany

  • University Hospital Tübingen

    RECRUITING

    Tübingen, Germany

  • University Medical Center Groningen (UMCG)

    NOT_YET_RECRUITING

    Groningen, Netherlands

  • University Medical Center, Hamburg Eppendorf

    RECRUITING

    Hamburg, Germany

  • University and Hospital of Padova

    RECRUITING

    Padova, Italy

  • University of Alberta

    RECRUITING

    Edmonton, Canada

  • University of Cincinnati

    SUSPENDED

    Cincinnati, Ohio, 45219, United States

  • University of Colorado

    RECRUITING

    Aurora, Colorado, 80045, United States

  • University of Maryland School of Medicine

    RECRUITING

    Baltimore, Maryland, 21201, United States

  • University of Pennsylvania

    SUSPENDED

    Philadelphia, Pennsylvania, 19104, United States

  • University of Toronto, Multiorgan Transplant Program

    RECRUITING

    Toronto, Canada

  • University of Utah Health

    RECRUITING

    Salt Lake City, Utah, 84132, United States

  • Universitätsklinikum Schleswig-Holstein (UKSH)

    NOT_YET_RECRUITING

    Kiel, Schleswig-Holstein, Germany

  • Universitätsklinikum Schleswig-Holstein (UKSH)

    RECRUITING

    Kiel, Germany

  • Vanderbilt University Medical Center

    NOT_YET_RECRUITING

    Nashville, Tennessee, 37232, United States

  • Walter Cantídio University Hospital

    RECRUITING

    Fortaleza, Brazil

  • Weill Cornell Medicine

    RECRUITING

    New York, New York, 10021, United States

  • Yashoda Hospitals

    NOT_YET_RECRUITING

    Secunderabad, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.