LIVER CIRRHOSIS

This study tests a new medicine called BI 3802876 in adults with compensated cirrhosis caused by MASH (a type of fatty liver disease). The main goal is to see if the drug is safe and how the body handles it. Participants receive either the drug or a placebo as an infusion, and ar…

This study compares two ways of placing a stent in the liver to prevent repeat bleeding from swollen veins in the throat or stomach in people with cirrhosis. The standard method fully expands the stent, while the new method uses a smaller balloon to keep it slightly narrower. The…

This study looks at whether eating protein evenly throughout the day, combined with a regular exercise program, can improve nutrition, muscle mass, and strength in people with end-stage liver disease awaiting a transplant. 90 participants will be split into three groups: one with…

This study compares early placement of a TIPS (a small tube that reroutes blood flow in the liver) against standard treatments like diuretics and fluid drainage in 134 patients with liver cirrhosis and ascites (fluid buildup). The goal is to see if TIPS improves survival and redu…

This study tests a drug called hydronidone in 300 adults with liver scarring (fibrosis or cirrhosis) from chronic hepatitis B. Participants take the drug three times daily for 28 days to see if it is safe. The main goal is to track any side effects.

This study tests whether taking capsules of processed donor stool (fecal transplant) can help people with liver cirrhosis avoid serious infections and hospital stays. About 300 adults with alcohol-related or fatty liver cirrhosis will receive either the transplant or a placebo an…

This study tests a technique called 'underdilated stent' during a liver shunt procedure (TIPS) for people with cirrhosis. The goal is to see if using a smaller balloon to place the stent can lower the risk of hepatic encephalopathy (brain confusion) after the procedure, while sti…

This study follows 30 adults with end-stage liver cirrhosis who receive a living-donor liver transplant. Researchers track bleeding and clotting complications to identify risk factors and improve prevention strategies. The goal is to make liver transplants safer in the early reco…

This study tests whether phycocyanin, a natural protein from spirulina, can improve liver health in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks. Researchers will measure changes in liver stiffness …

This study is testing a new, non-invasive way to detect high-risk varices (enlarged veins) in the esophagus and stomach of people with liver cirrhosis. Instead of using a camera down the throat (endoscopy), doctors will use a special ultrasound technique called SHAPE, along with …

This phase IV trial will enroll 5,500 people with liver cirrhosis or chronic hepatitis B—conditions that raise liver cancer risk. Participants are randomly assigned to either standard ultrasound screening or a new blood test called GALAD, which measures three proteins. The goal i…

This study aims to improve how doctors see liver damage (cirrhosis), liver cancer, and high blood pressure in the liver using a special PET/MRI scan. About 45 adults with cirrhosis will get this scan to see if it gives clearer pictures than current methods. The goal is to make di…

This study is testing a blood test called Elecsys® GAAD to see if it can detect liver cancer earlier in people with liver cirrhosis. Current methods often find cancer too late, leaving few treatment options. The study will compare the GAAD test with standard care in 600 participa…

This study tests whether a high-flow nasal cannula (HFNC) can prevent dangerous drops in oxygen levels during sedated gastrointestinal endoscopy in critically ill patients. Researchers will compare HFNC with standard nasal oxygen in 450 adults with serious health conditions. The …

This study is observing 1,000 people with liver cirrhosis who have bacterial infections and are being treated with β-lactam antibiotics. Researchers want to see how the body processes these drugs and whether personalized dosing could improve survival. The study is observational, …

This study is a registry that will follow 500 people with primary biliary cholangitis (PBC) in Austria. Researchers will collect medical data and optional blood or liver samples to learn how the disease progresses and what complications arise. No new treatment is being tested; th…

This study is collecting information from 10,000 liver transplant patients across Europe to create a new, up-to-date reference for what good outcomes look like when using machine perfusion (a technique that keeps donated livers healthier before transplant). The goal is to help do…

This study follows 2000 people with severe liver-related high blood pressure who receive a TIPS procedure, which creates a bypass in the liver. Researchers will track survival, need for liver transplant, and complications like confusion or liver failure over 12 months. The goal i…

This study looks at how blood clotting works differently in the liver's portal vein compared to the rest of the body in people with liver cirrhosis. Researchers will take blood samples from 45 patients during a routine procedure called TIPS, which helps relieve high blood pressur…

This study looks at whether easy-to-measure vital signs like heart rate and blood pressure can help predict how well people with liver cirrhosis and stomach bleeding will recover. Researchers will track 150 patients and use special scores based on these vital signs. The goal is t…

This early-stage study looks at how two common blood thinners, rivaroxaban and apixaban, behave in people with compensated liver cirrhosis. 24 participants receive a single dose of one drug, and researchers measure drug levels and blood clotting markers over 12 hours. The goal is…

This study is creating and testing a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness or trouble focusing, which are often missed. About 230 participants will fill out the questionnaire and t…

This study looks at whether handgrip strength—a simple measure of muscle function—can help predict changes in blood flow through the liver's main vein in people with cirrhosis. Researchers will measure blood pressure and flow in the portal vein and nearby veins before and after a…

This study looks at whether a special blood test called thrombelastography can help doctors decide when to give blood products to people with liver cirrhosis who are getting a TIPS shunt. The goal is to see if this test reduces the amount of blood products used and prevents bleed…

This study looks at how liver cirrhosis and liver transplantation affect hardening of the arteries (arterial calcification). Researchers will measure a substance called pyrophosphate in the blood and urine of 95 people waiting for a liver transplant. They want to see if the trans…

This study follows 3000 adults with severe liver failure who are being considered for a liver transplant. Researchers want to learn which patients benefit most from the procedure and how to improve survival. The goal is to better guide doctors in making this life-saving decision.

This study is testing a new scoring system called CAGIB to predict the risk of death in the hospital for people with liver cirrhosis who have sudden gastrointestinal bleeding. Researchers will compare CAGIB with two older scoring systems (Child-Pugh and MELD) in 3,000 patients ac…

This study reviews medical records of 600 adults with liver cirrhosis to see how often they visit doctors, get scans, or undergo procedures. Researchers want to understand what factors, like mental health, affect healthcare use. The goal is to find ways to improve care for people…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …

This study looks at how well people with alcohol-related liver cirrhosis understand health information and how confident they feel managing their condition. Researchers will survey 200 participants to measure these factors and track liver complications over time. The goal is to l…