LIVER CIRRHOSIS

This study tests a new way to place a stent (a small tube) in the liver to treat bleeding or fluid buildup caused by cirrhosis. The new technique uses a smaller balloon to keep the stent narrow at first, which may lower the chance of a brain complication called hepatic encephalop…

This study is for adults with end-stage liver disease who are waiting for a liver transplant. It compares three approaches: a diet with protein spread evenly across meals plus exercise, a diet with protein mostly at one meal plus exercise, or standard advice. The goal is to see w…

This study compares a procedure called TIPS (a small tube placed in the liver to redirect blood flow) against standard care (water pills and fluid drainage) in 134 adults with liver cirrhosis who have developed fluid buildup in the belly (ascites) for the first time. The goal is …

This study tests whether taking capsules containing healthy donor stool (fecal transplant) can help prevent serious infections and hospital stays in people with liver cirrhosis. About 300 adults with alcohol-related or fatty liver disease will receive either the transplant or a p…

This study tests whether phycocyanin, a natural protein from spirulina, can reduce liver damage and stiffness in adults with liver fibrosis or cirrhosis. Ten participants will take either phycocyanin or a placebo daily for at least 4 weeks, with regular blood tests and ultrasound…

This study compares two ways of doing a TIPS procedure (a shunt placed in the liver) to prevent dangerous rebleeding from enlarged veins in the esophagus or stomach in people with cirrhosis. The standard method uses an 8-mm balloon to open the shunt, while the experimental method…

This study looks at how well liver transplants work for people with severe acute-on-chronic liver failure (ACLF), a life-threatening condition. Researchers will track 3,000 adults with cirrhosis who are listed for a transplant to see who survives and how different transplant type…

This study tests a new medicine called BI 3802876 in 30 adults with liver scarring (cirrhosis) caused by MASH, a common liver disease. The main goal is to see if the drug is safe and how the body handles it. Participants receive either the drug or a placebo as an infusion, and ar…

This study tests a new way to manage bleeding risk in people with liver cirrhosis who need a TIPS procedure (a shunt placed in the liver). Instead of standard care, doctors will use a special blood test (thrombelastography) to decide if and when to give blood products before the …

This study tests a new, non-invasive way to find high-risk varices (enlarged veins) in the stomach and esophagus of people with liver cirrhosis. Instead of using a scope, doctors will combine a special ultrasound technique with liver stiffness measurements and a simple blood plat…

This study is testing a new blood test algorithm called GAAD to see if it can find liver cancer earlier in people with liver cirrhosis. Current methods often catch the cancer too late, leaving few treatment options. The study will compare the GAAD test with standard tests in 600 …

This study is testing a new type of PET/MRI scan to see if it can give doctors a clearer picture of liver cirrhosis, liver cancer, and related high blood pressure. About 45 adults with cirrhosis will get this scan. The goal is to improve how doctors detect and monitor these serio…

This study tests whether a blood test (GALAD) is better than ultrasound for finding liver cancer early in 5500 people with cirrhosis or chronic hepatitis B. Participants will be randomly assigned to one of two screening methods every six months. The goal is to see which approach …

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) can reduce the risk of dangerously low oxygen levels during sedated gastrointestinal endoscopy in critically ill patients. About 450 adults with serious health conditions…

This study follows 10,000 adults with advanced chronic liver disease to see how their health changes over time. Researchers will collect medical data and samples like blood, urine, and tissue to better understand cirrhosis and its complications. Participants receive regular check…

This study looks at how two common blood thinners, rivaroxaban and apixaban, are processed by the body in people with mild to moderate liver cirrhosis. 24 adults with compensated cirrhosis will receive a single dose of one of the drugs, and their blood will be tested over 12 hour…

This study involves 30 adults with end-stage liver cirrhosis who are receiving a living-donor liver transplant. Researchers want to find out what factors increase the risk of dangerous bleeding or blood clots after surgery. The goal is to create a better prevention plan to improv…

This study aims to create and test a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness and trouble focusing, which are often missed in regular checkups. About 230 participants will fill out th…

This study looks back at medical records of 600 adults with liver cirrhosis to understand how often they use healthcare services like doctor visits, scans, and procedures. The goal is to find patterns and factors, such as social or emotional issues, that affect healthcare use. No…

This study looks at why people with liver cirrhosis sometimes develop blood clots in the portal vein (the main vein to the liver). Researchers will compare blood clotting activity in the general bloodstream versus directly in the liver's portal vein during a routine procedure cal…

This study follows 2000 people with severe high blood pressure in the liver (portal hypertension) who receive a procedure called TIPS, which creates a bypass to reduce pressure. Researchers will track survival, need for liver transplant, and complications like confusion or liver …

This study looks at whether easy-to-measure vital signs like heart rate and blood pressure can help predict how well people with liver cirrhosis recover from a stomach bleeding episode. Researchers will track 150 patients and use special scores based on these vital signs. The goa…

This study looks at how liver cirrhosis and liver transplants affect artery calcification (hardening of the arteries). Researchers will measure changes in artery calcification and a substance called pyrophosphate in 95 adults before and after liver transplantation. The goal is to…

This study looks at 200 adults with alcohol-related liver cirrhosis to measure their health literacy (understanding health information) and self-efficacy (confidence in managing their health). Researchers will track how these factors relate to serious liver events and hospital re…

This study looks at whether handgrip strength—a simple measure of muscle function—is linked to blood flow changes in the liver's main vein (portal vein) in people with liver cirrhosis. Researchers will measure pressure, speed, and direction of blood flow using different methods (…