LIVER CIRRHOSIS

This study tested whether using a patient's own stem cells could help improve liver function in people with advanced liver scarring (cirrhosis). Researchers followed 700 patients with cirrhosis caused by hepatitis viruses or fatty liver disease to see if stem cell therapy was saf…

This study tested whether a combination of two drugs (zibotentan and dapagliflozin) is safe for people with liver cirrhosis. Researchers compared the combination against each drug alone and against a placebo in 73 patients across multiple countries. The main goal was to monitor s…

This study tested a new smartphone app called ReLiver-N, designed to help people with liver cirrhosis better manage their condition. For 90 days, 48 patients used the app to track symptoms, receive health education, and get feedback on their daily care. Researchers wanted to see …

This study tested if doses of blood pressure drugs predicted by a computer program were safe and effective for people who have both high blood pressure and liver cirrhosis. Forty patients were given either nebivolol or carvedilol at the computer-suggested dose. Researchers monito…

This study tested whether a telemedicine app called myLIVERcoach is a practical tool for people with liver cirrhosis. 50 patients and their caregivers used the app alongside regular care for 6 months to report symptoms and learn about their condition. Researchers wanted to see if…

This study tested whether adding the protein albumin to the blood pressure medication midodrine works better than midodrine alone to prevent serious complications in children with advanced liver cirrhosis and fluid buildup in the abdomen. The goal was to see if the combination co…

This study tested whether a repurposed growth hormone treatment could help patients with advanced, decompensated liver cirrhosis. It aimed to see if the hormone could improve survival without a transplant, reduce serious complications, and help rebuild muscle and immune function.…

This small, early-stage study tested whether stem cells from umbilical cords are safe and can help improve liver function in adults with cirrhosis. Twenty patients received the stem cell treatment and were monitored for a year for side effects and changes in their liver health sc…

This study looked at how well and how safely a newer combination drug treatment (Atezolizumab-Bevacizumab) works for advanced liver cancer in patients who also have liver scarring (cirrhosis), compared to an older type of drug (TKIs). Researchers followed 38 real-world patients t…

This small pilot study tested whether using a computer model to predict safe, personalized doses of the cholesterol drug simvastatin could help control portal hypertension in people with liver cirrhosis. Over three months, 22 patients with mild-to-moderate cirrhosis received eith…

This study directly compared two methods for taking a small sample of liver tissue to diagnose disease. Researchers tested whether a newer method using a scope through the stomach (EUS) was as good as the standard method using a needle through the skin (percutaneous). They measur…

This study tested a special type of ultrasound scan (CEUS) to see if it could better identify unusual spots found on the liver. Researchers wanted to know if this method could provide clearer answers without needing more expensive scans or invasive biopsies. They enrolled 878 peo…

This study tested whether a sleep medicine called lemborexant is safe and effective for people with liver cirrhosis who have trouble sleeping. It involved 82 adults with cirrhosis and poor sleep, comparing the drug to a placebo. The goal was to see if it improved sleep quality wi…

This study aimed to understand how comfortable and skilled liver cirrhosis patients are with finding and understanding health information online. Researchers asked 86 patients to complete two questionnaires about their digital health experiences. The goal was to gather informatio…

This study aimed to understand how liver cirrhosis affects the way the body processes common medicines. Researchers compared healthy adults to adults with mild or moderate liver cirrhosis. All participants took a single, safe dose of five different approved medicines, and doctors…

This study aimed to understand how a common antibiotic, ceftriaxone, moves through and is cleared from the bodies of patients with severe, decompensated liver cirrhosis. Researchers observed 20 hospitalized patients who were already receiving this antibiotic and having a procedur…

This early-stage study aimed to understand how the experimental drug zibotentan is absorbed, distributed, and eliminated by the body in healthy volunteers. It involved 30 healthy Japanese and non-Asian participants who each received four different single doses of the drug over se…

This study looked back at medical records to understand how well a standard treatment works for patients with both sudden kidney failure and advanced liver disease, who also had signs of pre-existing chronic kidney problems. Researchers compared 490 hospitalized patients who rece…

This study tested a new scoring system called the ICCO score to see how well it could predict survival for people with advanced liver disease (cirrhosis) who are admitted to the intensive care unit (ICU). Researchers enrolled 150 patients to calculate the ICCO score and compare i…

This study aimed to understand how liver cirrhosis affects how the body processes medicines. Researchers compared healthy adults to adults with liver cirrhosis by giving them single doses of four common drugs (rosuvastatin, digoxin, metformin, and furosemide) and measuring drug l…

This study followed 100 adults hospitalized with liver cirrhosis to track what happened to them over 90 days after admission. Researchers wanted to understand how many patients passed away during this period and identify which factors put patients at higher risk. The goal was to …