LIVER CIRRHOSIS

Liver cirrhosis often causes muscle weakness and frailty, even in stable patients. This study tested whether a personalized diet with extra calories and protein, along with nutrition counseling, could improve muscle strength and quality of life. About 70 adults with stable cirrho…

This completed phase 2 trial tested a drug called foscenvivint in just 5 people with liver cirrhosis caused by HIV and hepatitis C co-infection who also have hemophilia. The goal was to see if the drug could improve liver function scores over 24 weeks. Because the study is very s…

This completed Phase 3 trial tested whether fecal microbiota transplantation (FMT) could help people with liver cirrhosis. Nineteen patients received FMT via colonoscopy. Researchers measured liver stiffness and signs of brain confusion (hepatic encephalopathy) one month later. T…

This study tested whether giving both midodrine (a blood-pressure drug) and albumin (a protein infusion) to children with cirrhosis and fluid buildup (ascites) could prevent serious complications like kidney injury, low sodium, and confusion. Sixty-one children were split into tw…

This study tested a smartphone app called ReLiver-N designed to help people with liver cirrhosis take a more active role in their care. The app provides health education, self-management tools, and a system to flag urgent issues. Researchers enrolled 48 patients with mild to mode…

This study tested whether a computer program (Simcyp) could predict the right doses of two blood pressure drugs, nebivolol and carvedilol, for people with liver cirrhosis and high blood pressure. Forty patients were randomly assigned to one of the two drugs and monitored for thre…

This early-stage trial tested whether stem cells from donated umbilical cords are safe for people with liver cirrhosis. Twenty adults received an infusion of these cells and were monitored for a year. The main goal was to check for side effects, but researchers also looked for si…

This study tested whether a combination of two drugs, zibotentan and dapagliflozin, is safe for people with cirrhosis, a serious liver condition. 73 adults with cirrhosis took part, receiving either the drug combo, zibotentan alone, or a placebo. The main goal was to check for si…

This completed phase 3 study followed 700 people with liver cirrhosis caused by hepatitis B, C, or fatty liver disease. Researchers took a small amount of bone marrow from each patient, processed it to collect stem cells, and infused those cells back into the patient. The goal wa…

This study tested whether giving growth hormone to people with decompensated liver cirrhosis (advanced liver scarring) could improve their health and survival. The trial included 96 adults with this condition. Researchers measured how long patients survived without major complica…

This study tested whether nifuroxazide, a drug used for gut infections, can help treat hepatic encephalopathy—a condition where liver disease causes confusion and brain fog. Researchers gave the drug to 80 hospitalized patients with moderate to severe symptoms. The goal was to se…

This study looked at whether measuring tiny molecules called microRNAs in the blood can help diagnose liver cancer (hepatocellular carcinoma) in people with hepatitis C. Researchers tested blood samples from 84 participants, including healthy people and those with hepatitis C, wi…

This study compared two methods of taking a liver tissue sample: one using an endoscope with ultrasound (EUS) and the other using a needle through the skin (percutaneous). Researchers wanted to see which method provides better samples for diagnosing liver disease. The trial invol…

This study tested whether a special ultrasound with contrast dye (CEUS) can more accurately identify liver lesions than standard ultrasound or other imaging methods like CT and MRI. Researchers enrolled 878 participants with liver lesions found on standard ultrasound. The goal wa…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The drug works by blocking wakefulness signals in the brain. Researchers measured sleep quality and checked for side effects on the liver. The goal was to see if le…

This study tests whether a special capsule, called SIMBA, can safely collect fluid from the small intestine in people with liver cirrhosis. Participants swallow two capsules, which are later recovered from stool. Researchers will analyze the fluid to compare gut bacteria and meta…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to understand normal stiffness values and how they change with disease or treatment. This is an observa…

This study tested whether a computer program (Simcyp) could help doctors choose the right starting dose of warfarin, a blood thinner, for 21 patients with liver cirrhosis and a blood clot in the portal vein. The goal was to see if the program helped patients reach a safe, effecti…

This study looked at 211 people with liver cirrhosis to see which screening method works better for detecting liver cancer: an ultrasound every 6 months or an MRI once a year. Participants received both tests, and researchers measured how often each test correctly found cancer. T…

This study looked at how blood clots in people with liver cirrhosis, a condition that can cause bleeding problems. Researchers used a special machine called T-TAS to measure clotting in blood samples from 60 patients. They also tested whether tiny particles that act like platelet…

This study looked at how often acute kidney injury happens in people with liver cirrhosis, and what factors might increase the risk. Researchers at Sohag University Hospital followed 180 adult patients with cirrhosis, excluding those with pre-existing kidney disease or other majo…

This study looked at 64 adults with liver cirrhosis and a history of variceal bleeding who were scheduled for a TIPS procedure. Researchers measured handgrip strength and then checked how it changed blood pressure in the portal and left gastric veins. The goal was to see if muscl…

This early-phase study looked at how the body breaks down nalbuphine extended-release tablets in people with mild, moderate, or severe liver impairment compared to healthy volunteers. It also explored whether the drug could relieve itching in those with liver problems. The study …

This study looked at how safe and effective a combination of two drugs (Atezolizumab and Bevacizumab) is for people with liver cancer and cirrhosis, compared to standard pills (tyrosine kinase inhibitors). Researchers followed 38 patients to see how long they lived and how their …

This study tested whether a computer program could help doctors choose the right dose of simvastatin for people with cirrhosis and high blood pressure in the liver. Twenty-two patients received either 5 mg or 15 mg of simvastatin daily for three months. Researchers measured chang…

This study tested a new scoring system called the Intensive Care Cirrhosis Outcome (ICCO) score to see how well it predicts survival in cirrhosis patients admitted to the ICU. Researchers calculated the score for 150 adult patients using routine lab tests and tracked their outcom…

This study looked at whether measuring liver pressure during an endoscopy is more accurate when patients lie on their left side versus flat on their back. Researchers tested 30 hospitalized patients with liver cirrhosis. The goal was to see if the two positions give consistent re…

This study tested a telemedicine platform called myLIVERcoach in 50 adults with liver cirrhosis. Participants used the app alongside standard care to answer questionnaires and track symptoms, aiming to catch complications early. The goal was to see if patients, caregivers, and do…

This study looked at how the body processes four common drugs (rosuvastatin, digoxin, metformin, and furosemide) in healthy people and those with liver cirrhosis. Researchers measured drug levels in the blood to see if liver disease changes how these medicines are handled. The go…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver disease and fluid buildup (ascites). Researchers collected leftover blood and fluid samples to measure drug levels. The goal was to better understand dosing …

This completed study from University Hospital Freiburg looked back at 490 patients with liver cirrhosis and signs of chronic kidney disease who were treated for hepatorenal syndrome. Researchers compared how well patients with and without pre-existing kidney disease responded to …

This study looked at how the drug zibotentan is absorbed and cleared by the body in 30 healthy adults, including both non-Asian and Japanese participants. It was a phase 1 trial, meaning it was an early step to gather safety and drug-level information. The study did not aim to tr…

This study looked at 100 adults hospitalized with liver cirrhosis to see how many survived within 90 days and what factors increased their risk of death. Researchers collected basic health information and followed patients for three months. The goal was to better understand which…

This study looked at how well people with liver cirrhosis can find and understand health information online. 86 patients filled out two questionnaires about their digital skills and ability to read health charts. The goal was to learn about their digital health literacy, not to t…

This completed study looked at how people with and without liver cirrhosis process five common medicines: caffeine, warfarin, omeprazole, metoprolol, and midazolam. Only 4 participants took part, including healthy volunteers and those with mild or moderate cirrhosis. Researchers …