LIVER CIRRHOSIS

This study tested whether a combination of two drugs, zibotentan and dapagliflozin, is safe for people with liver cirrhosis. 73 adults with cirrhosis took either the combination, zibotentan alone, or a placebo. The main goal was to see if the drugs caused fluid retention, a commo…

This study tested whether giving growth hormone to people with advanced liver cirrhosis could improve their health and survival. 96 adults with decompensated cirrhosis (where the liver is failing) received either growth hormone or a placebo for several months. The goal was to see…

This early-stage trial tested whether stem cells from donated umbilical cords are safe and can help adults with liver cirrhosis. Twenty participants received the stem cells and were monitored for side effects and changes in liver function over a year. The goal is to see if this a…

This study tested whether a fecal transplant (transferring healthy bacteria from a donor's stool) could help people with liver cirrhosis. Nineteen adults received the transplant, and researchers measured liver stiffness and brain function one month later. The goal was to see if t…

This study looked at 61 children with severe liver scarring (cirrhosis) and fluid buildup in the belly (ascites). Researchers wanted to see if giving two drugs together—midodrine (raises blood pressure) and albumin (a protein that helps circulation)—works better than midodrine al…

This small study tested a drug called foscenvivint in 5 people with liver cirrhosis caused by both HIV and hepatitis C, who also have hemophilia. The goal was to see if the drug could improve liver function and was safe. Participants had well-controlled HIV and had been cured of …

This study looked at the long-term safety and effects of using a patient's own stem cells to treat liver cirrhosis caused by hepatitis B, C, or fatty liver disease. 700 adults with compensated cirrhosis were monitored after receiving the therapy. The goal was to see if the treatm…

This study tested a smartphone app called ReLiver-N, designed to help people with liver cirrhosis take a more active role in their care. The app provides health education, self-management tools, and a system to alert nurses if a patient's condition changes. Researchers wanted to …

This study tested whether a computer program (Simcyp) could help predict the right dose of two blood pressure drugs (nebivolol and carvedilol) for 40 people with liver cirrhosis and high blood pressure. Participants were split by liver disease severity and given the closest avail…

This study tested a special ultrasound (CEUS) that uses a contrast dye to get clearer images of liver spots found on regular ultrasound. The goal was to see if CEUS can accurately tell if a spot is cancerous or not, potentially avoiding the need for more expensive or invasive tes…

This study tested a sleep medication called lemborexant in 82 adults with liver cirrhosis who had trouble sleeping. The goal was to see if the drug could improve sleep quality safely. The approach used a drug that works differently from common sleep aids to avoid liver-related ri…

This study tested a new ultrasound technique called ARFI to measure liver stiffness in 109 people, including healthy volunteers and patients with liver conditions. The goal was to find normal stiffness values and see how reproducible the measurements are. This research helps impr…

This study looked at how the drug zibotentan moves through the bodies of healthy non-Asian and Japanese volunteers. Thirty people took a single dose, and researchers measured drug levels and checked for side effects. The goal was to gather information, not to treat any disease.

This study looked at how blood clotting works in people with liver cirrhosis, a condition that can cause dangerous bleeding. Researchers used a special machine called T-TAS to measure clotting under flow conditions, which is more realistic than standard tests. They also tested wh…

This study looked at 211 adults with liver cirrhosis to see which imaging test works better for catching liver cancer early: an ultrasound every 6 months or an MRI without contrast dye once a year. The goal was to find out which test is more accurate and reduces false alarms. Res…

This study looked at how the antibiotic ceftriaxone moves through the blood and belly fluid in 20 people with severe liver cirrhosis and fluid buildup (ascites), some of whom also had kidney problems. Researchers collected leftover blood and fluid samples during routine care to m…

This study looked at how well two different treatments work in real life for people with advanced liver cancer and cirrhosis. Researchers compared a combination of two drugs (Atezolizumab and Bevacizumab) to a group of similar patients who took a different type of drug (tyrosine …

This study looked at 100 adults with liver cirrhosis who were admitted to the hospital. The goal was to track how many patients died within 90 days and find out what factors increased their risk. No new treatments were tested; instead, researchers collected data to better underst…

This study tested a telemedicine app called myLIVERcoach for people with liver cirrhosis. The goal was to see if using the app to track symptoms and communicate with healthcare providers is practical and helpful. 50 patients and their caregivers used the app for six months alongs…

This study looked at how four common medicines (rosuvastatin, digoxin, metformin, and furosemide) are processed in healthy adults and in people with liver cirrhosis. Researchers measured drug levels in the blood to see if liver disease changes how the body handles these drugs. Th…

This study tested whether a computer program could help doctors choose the right dose of a common cholesterol drug (simvastatin) for people with liver cirrhosis and high blood pressure in the liver. Twenty-two adults with mild to moderate cirrhosis took part. The goal was to see …

This study tested whether a computer program (Simcyp) could help doctors choose the right starting dose of warfarin, a blood thinner, for 21 patients with liver cirrhosis and a blood clot in the portal vein. The goal was to reach a safe and effective level of blood thinning more …

This study compared two methods of taking a liver biopsy: one using an endoscope with ultrasound (EUS) and the other using a needle through the skin (percutaneous). The goal was to see which method collects better tissue samples for diagnosing liver diseases like cirrhosis. 90 ad…

This study looked back at medical records of 490 people with liver cirrhosis and kidney problems to see how well a treatment (terlipressin and albumin) worked. The goal was to compare treatment response in patients with and without chronic kidney disease. The study is complete an…

This study looked at 150 adults with liver cirrhosis admitted to the intensive care unit (ICU). Researchers calculated a special score (ICCO) using blood tests to see if it could predict which patients would survive. The goal is to help doctors make better decisions for criticall…

This study looked at how comfortable and skilled people with liver cirrhosis are with digital health tools like online health information and visual aids. 86 patients filled out two questionnaires about their digital health literacy and ability to understand health visuals. The r…

This study looked at how the body handles five common drugs (caffeine, warfarin, omeprazole, metoprolol, and midazolam) in healthy adults and in people with mild or moderate liver cirrhosis. Researchers measured drug levels in the blood to see if liver scarring changes how these …