Liver cirrhosis study reveals how common drugs behave differently

NCT ID NCT05741372

Completed Knowledge-focused Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how the body processes four common drugs (rosuvastatin, digoxin, metformin, and furosemide) in healthy people and those with liver cirrhosis. Researchers measured drug levels in the blood to see if liver disease changes how these medicines are handled. The goal is to improve future drug dosing for people with liver cirrhosis.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Rosuvastatin, digoxin, metformin, furosemide
What this could lead to: If successful, this study could help doctors prescribe safer, more effective doses of certain drugs for people with liver cirrhosis.
What could go wrong: This is a small, completed observational study, not a treatment trial. Results may not apply to all patients or drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER CIRRHOSIS

Contacts and locations

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Locations

CRS Clinical Research Services Mannheim GmbH

Mannheim, 68167, Germany

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