Blood test aims to outshine ultrasound for liver cancer detection

NCT ID NCT03694600

Ongoing Diagnosis Sponsor: Helio Genomics Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This trial is testing a blood test that looks for DNA markers of liver cancer in people with liver cirrhosis, who are at high risk for developing the disease. The test is compared to standard ultrasound to see which method is better at detecting liver cancer. If the blood test proves accurate, it could offer a less invasive and more convenient screening option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Multi-analyte blood test
What this could lead to: If successful, this blood test could offer a simpler, more accurate way to screen for liver cancer in high-risk people with cirrhosis, potentially catching tumors earlier.
What could go wrong: The test is still being evaluated and may not prove more effective than standard ultrasound. False positives or negatives could occur, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cirrhosis of liver

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER CIRRHOSIS

Contacts and locations

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Locations

AZ Liver Health (Chandler)

Chandler, Arizona, 85224, United States
AZ Liver Health (Glendale, Peoria)

Peoria, Arizona, 85381, United States
AZ Liver Health (Tucson)

Tucson, Arizona, 85712, United States
Alliance Research Centers

Irvine, California, 92612, United States
Atlanta Gastroenterology

Atlanta, Georgia, 30308, United States
Banner University Hospital (University of Arizona Tucson)

Tucson, Arizona, 85724, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Covenant Metabolic LLC

Fort Myers, Florida, 33012, United States
Covenant Metabolics LLC

Sarasota, Florida, 34240, United States
Digestive & Liver Disease Specialists (DLDS) - Norfolk

Norfolk, Virginia, 23502, United States
Gastro One in Memphis

Memphis, Tennessee, 38104, United States
Gastroenterology Group of Naples

Naples, Florida, 34102, United States
Harborview Medical Center (University of Washington)

Seattle, Washington, 98104, United States
Impact Research Institute

Waco, Texas, 76710, United States
Kansas City Research Institute (KCRI)

Kansas City, Missouri, 64131, United States
Konkord Research

Houston, Texas, 77065, United States
Liver Center of Texas

Dallas, Texas, 75234, United States
Liver Institute Northwest

Seattle, Washington, 98105, United States
Louisiana Research Center, LLC

Shreveport, Louisiana, 71105, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
Methodist Dallas Medical Center

Dallas, Texas, 79936, United States
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
PMG Research of Winston-Salem

Winston-Salem, North Carolina, 27103, United States
Piedmont Research Institute

Atlanta, Georgia, 30309, United States
Quality Medical

Nashville, Tennessee, 37211, United States
SouthTexas Research Institute

Edinburg, Texas, 78539, United States
St Luke's Hospital of Kansas City

Kansas City, Kansas, 64111, United States
Stanford University

Palo Alto, California, 94304, United States
Texas Gastro Clinic

El Paso, Texas, 79936, United States
Texas Liver Institute - American Research Corp.

San Antonio, Texas, 78215, United States
Tulane University Health Sciences Center

New Orleans, Louisiana, 70112, United States
University of Cincinnati College of Medicine

Cincinnati, Ohio, 45627, United States
University of Colorado Hospital - Anschutz Cancer Pavilion

Aurora, Colorado, 80045, United States
University of Florida Clinical and Translational Science Institute

Gainesville, Florida, 32610, United States
University of Louisville

Louisville, Kentucky, 40202, United States
University of Miami - Schiff Center for Liver Diseases

Miami, Florida, 33136, United States
University of South California

Los Angeles, California, 90033, United States
VA Richmond

Richmond, Virginia, 23249, United States

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