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Blood test and AI could spot liver cancer early, saving lives

NCT ID NCT04965259

Ongoing Knowledge-focused Sponsor: National Cancer Centre, Singapore Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study follows 2,002 people at high risk for liver cancer to find better ways to detect it early. Researchers are testing a panel of blood-based miRNA markers, gut microbiome changes, and MRI-based AI algorithms to predict who develops the disease. The goal is to improve on current surveillance methods, which miss about 37% of early-stage cancers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a simple blood test and AI-based imaging to catch liver cancer early, when it is curable.
What could go wrong
This is an observational study, not a treatment trial. The biomarkers may not prove accurate enough for widespread use, and results may take years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis B virus infection chronic hepatitis C virus infection cirrhosis of liver hepatocellular carcinoma liver disorder metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIVER DISEASES

Contacts and locations

Locations

  • Changi General Hospital

    Singapore, 529889, Singapore

  • National Cancer Center Singapore

    Singapore, 168583, Singapore

  • National University Hospital

    Singapore, 119228, Singapore

  • Sengkang General Hospital

    Singapore, 544886, Singapore

  • SingHealth Polyclinics - Bedok

    Singapore, 469662, Singapore

  • SingHealth Polyclinics - Bukit Merah

    Singapore, 150163, Singapore

  • SingHealth Polyclinics - Marine Parade

    Singapore, 440080, Singapore

  • SingHealth Polyclinics - Outram

    Singapore, 168937, Singapore

  • SingHealth Polyclinics - Pasir Ris

    Singapore, 519457, Singapore

  • SingHealth Polyclinics - Punggol

    Singapore, 820681, Singapore

  • SingHealth Polyclinics - Sengkang

    Singapore, 545025, Singapore

  • SingHealth Polyclinics - Tampines

    Singapore, 529203, Singapore

  • Singapore General Hospital

    Singapore, 169608, Singapore

  • Tan Tock Seng Hospital

    Singapore, 308433, Singapore

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