Swallowable capsule could unlock secrets of Gut-Liver connection
NCT ID NCT06708832
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a special capsule, called SIMBA, can safely collect fluid from the small intestine in people with liver cirrhosis. Participants swallow two capsules, which are later recovered from stool. Researchers will analyze the fluid to compare gut bacteria and metabolites with those found in mouth and stool samples. The goal is to see if this method works and could help understand how the small intestine microbiome relates to liver disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- SIMBA capsule (Small Intestine Microbiome Aspiration capsule)
- What this could lead to
- If successful, this method could help researchers better understand how gut bacteria in the small intestine affect liver disease, potentially pointing toward new treatments.
- What could go wrong
- This is a very small pilot study with only 11 participants, focused on feasibility. The capsule may not always collect enough fluid, and results may not apply to all cirrhosis patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Liver study clinic
Graz, 8010, Austria
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Other studies related to the condition(s) this trial covers.
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