Swallowable capsule could unlock secrets of Gut-Liver connection
NCT ID NCT06708832
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a special capsule, called SIMBA, can safely collect fluid from the small intestine in people with liver cirrhosis. Participants swallow two capsules, which are later recovered from stool. Researchers will analyze the fluid to compare gut bacteria and metabolites with those found in mouth and stool samples. The goal is to see if this method works and could help understand how the small intestine microbiome relates to liver disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SIMBA capsule (Small Intestine Microbiome Aspiration capsule)
What this could lead to
If successful, this method could help researchers better understand how gut bacteria in the small intestine affect liver disease, potentially pointing toward new treatments.
What could go wrong
This is a very small pilot study with only 11 participants, focused on feasibility. The capsule may not always collect enough fluid, and results may not apply to all cirrhosis patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Internal Medicine, Division of Gastroenterology and Hepatology, Liver study clinic
Graz, 8010, Austria