Could a common gut drug clear brain fog in liver patients?
NCT ID NCT05754996
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether nifuroxazide, a drug used for gut infections, can help treat hepatic encephalopathy—a condition where liver disease causes confusion and brain fog. Researchers gave the drug to 80 hospitalized patients with moderate to severe symptoms. The goal was to see if it could reverse the brain symptoms faster than standard care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nifuroxazide
What this could lead to
If it works, nifuroxazide could offer a new treatment option for hepatic encephalopathy, potentially improving mental status and reducing hospital stays.
What could go wrong
This is a small pilot study with only 80 participants, so results may not apply to everyone. Side effects like abdominal pain, nausea, and headache are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Hepatology and Tropical Medicine Research Institute (NHTMRI)
Cairo, Egypt