HEPATIC ENCEPHALOPATHY

This study tests whether two drugs that calm the immune system—high-dose steroids or anti-thymocyte globulin—can help children with sudden, severe liver failure survive without needing a liver transplant. About 163 children aged 1 to 17 will be randomly assigned to receive one of…

This study looks at whether giving a protein called albumin through a vein can help improve thinking and memory in people with liver cirrhosis who have had episodes of confusion (hepatic encephalopathy). The trial will involve 30 participants who will receive both albumin and a p…

This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either api…

This study tests whether taking a protein supplement (Ensure Enlive) in the late evening and early morning can reduce hospital readmissions for people with hepatic encephalopathy, a brain condition caused by liver disease. The trial enrolls 40 adults with cirrhosis who have been …

This study is creating and testing a new questionnaire called LiCCoS for adults with liver cirrhosis. The goal is to help identify common thinking problems like forgetfulness or trouble focusing, which are often missed. About 230 participants will fill out the questionnaire and t…

This pilot study at Mayo Clinic is testing whether a dietary supplement called resistant potato starch can change gut bacteria in people with cirrhosis who have had episodes of confusion (hepatic encephalopathy). Eleven participants will take 20 grams of potato starch twice daily…

This study follows 10,000 people with advanced chronic liver disease at Vienna General Hospital. Researchers will track their health over time, collect blood, urine, and tissue samples, and record complications like bleeding or liver failure. The goal is to better understand how …