Could a blood thinner and heart pill prevent deadly liver complications?
NCT ID NCT07521332
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the blood thinner apixaban to the heart drug carvedilol can prevent complications like bleeding, fluid buildup, and confusion in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will take either apixaban plus carvedilol or a placebo plus carvedilol for 12 months. Researchers will track how many develop serious liver-related events and monitor bleeding risks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Apixaban and carvedilol
- What this could lead to
- If it works, this combination could reduce serious complications like variceal bleeding and fluid buildup in people with cirrhosis.
- What could go wrong
- This is a single-blind, phase 4 trial in one hospital in Pakistan, so results may not apply broadly. Apixaban also raises bleeding risk, which is especially dangerous in liver disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ASCITES are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Asian Institute of Medical Sciences
RECRUITINGHyderābād, Sindh, 71000, Pakistan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can everyday drugs shield the liver from Cirrhosis's worst threats?
- A new procedure may offer relief for Cirrhosis-Related fluid buildup
- Can extra doses of an old drug reverse liver scarring?
- Could a yellow tinge predict dangerous hospital infections?
- Muscle quality on MRI may foretell liver transplant success
- Melatonin may ease sleep and brain fog in liver disease — a trial puts it to the test