PORTAL HYPERTENSION

This study compares two medications, terlipressin and somatostatin, to see which one better lowers high blood pressure in the liver's main vein during a living-donor liver transplant. High pressure there can cause dangerous bleeding. About 50 adults with severe liver disease and …

This study tests whether adding the blood thinner apixaban to the standard drug carvedilol can prevent serious complications like bleeding, fluid buildup, and liver failure in people with cirrhosis and high blood pressure in the liver. About 220 adults with stable cirrhosis will …

This study is checking how well a medical device called the Cera Vascular Plug works and if it is safe. The plug is used to block blood flow in certain blood vessels to treat conditions like aneurysms (bulging arteries) or abnormal connections between arteries and veins. About 13…

This study tests a noninvasive ultrasound method called SHAPE to detect portal hypertension (high blood pressure in the liver). Currently, diagnosis requires a risky catheter procedure. The trial will enroll 60 adults scheduled for the standard test to see if the ultrasound techn…

This study is testing a new type of PET/MRI scan to see if it can give doctors a clearer picture of liver cirrhosis, liver cancer, and related high blood pressure. About 45 adults with cirrhosis will get this scan. The goal is to improve how doctors detect and monitor these serio…

This study follows 10,000 adults with advanced chronic liver disease to see how their health changes over time. Researchers will collect medical data and samples like blood, urine, and tissue to better understand cirrhosis and its complications. Participants receive regular check…

This study looks at a procedure called TIPS used to treat complications of portal hypertension (high blood pressure in the liver) in people with a rare liver disease called Porto-Sinusoidal Vascular Disease (PSVD). Researchers will compare outcomes in 360 patients with PSVD to si…

This study looks at why people with liver cirrhosis sometimes develop blood clots in the portal vein (the main vein to the liver). Researchers will compare blood clotting activity in the general bloodstream versus directly in the liver's portal vein during a routine procedure cal…

This study is testing a new, less risky method to measure pressure in the liver's blood vessels using an endoscope with ultrasound. The goal is to see if this measurement can help predict serious problems like bleeding or fluid buildup in people with chronic hepatitis and cirrhos…

This study is creating a large collection of medical data and samples from 1,000 people with portal hypertension, a condition that can cause dangerous bleeding in the esophagus or stomach. The goal is to use advanced technologies like genetics and artificial intelligence to bette…

This study is testing a blood test called hepatomiR to see if it can predict when people with chronic liver disease will develop serious complications like fluid buildup in the belly, bleeding in the stomach, or confusion. The goal is to better understand what leads to these even…

This study tests if a new, less invasive method using an endoscope with ultrasound can accurately measure blood pressure in the liver, compared to the standard method. About 40 adults with liver disease will have both measurements taken during one session. The goal is to see if t…

This study looks at whether handgrip strength—a simple measure of muscle function—is linked to blood flow changes in the liver's main vein (portal vein) in people with liver cirrhosis. Researchers will measure pressure, speed, and direction of blood flow using different methods (…

This study is testing whether a special 3D MRI scan (called 3D-MRE) can accurately measure liver pressure in people with cirrhosis or advanced liver disease. Currently, doctors must insert a thin tube into a neck vein to measure this pressure. If the scan works, it could offer a …